Sorafenib-Loaded Silica-Containing Redox Nanoparticle Decreases Tumorigenic Potential of Lewis Lung Carcinoma

Sorafenib-Loaded Silica-Containing Redox Nanoparticle Decreases Tumorigenic Potential of Lewis Lung Carcinoma

<b>Background:</b> Orally administered sorafenib has shown limited improvement in overall survival for non-small-cell lung cancer patients, likely due to poor pharmacokinetics and adverse effects, including gastrointestinal toxicity. To address these issues, we developed silica-containin...

Full description

Saved in:

Bibliographic Details
Main Authors:	Babita Shashni, Hao Thi Tran, Long Binh Vong, Ren-Jei Chung, Yukio Nagasaki
Format:	Article
Language:	English
Published:	MDPI AG 2025-01-01
Series:	Pharmaceutics
Subjects:	oral drug delivery system polymeric micelles sorafenib antioxidant nanocarrier lung cancer
Online Access:	https://www.mdpi.com/1999-4923/17/1/50
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The Transcription Factor Creb is Involved in Sorafenib-Inhibited Renal Cancer Cell Proliferation, Migration and Invasion
by: Huang Shuaishuai, et al.
Published: (2018-12-01)

Phase II study with sorafenib plus radiotherapy for advanced HCC with portal and/or hepatic vein tumor thrombosis
by: Yirui Zhai, et al.
Published: (2025-03-01)

Lenvatinib versus sorafenib as second-line therapy following progression on atezolizumab–bevacizumab in patients with unresectable hepatocellular carcinoma: a multicenter retrospective study from Korea and Japan
by: Jaekyung Cheon, et al.
Published: (2025-01-01)

Sorafenib enhanced the function of myeloid-derived suppressor cells in hepatocellular carcinoma by facilitating PPARα-mediated fatty acid oxidation
by: Chunxiao Li, et al.
Published: (2025-01-01)

ANGPTL3 overcomes sorafenib resistance via suppression of SNAI1 and CPT1A in liver cancer
by: Yang-Hsiang Lin, et al.
Published: (2025-02-01)

Development of a Cationic Polymeric Micellar Structure with Endosomal Escape Capability Enables Enhanced Intramuscular Transfection of mRNA-LNPs
by: Siyuan Deng, et al.
Published: (2024-12-01)

HTR1D regulates the PI3K/Akt signaling pathway to impact hepatocellular carcinoma development and resistance to sorafenib
by: Yingai Zhang, et al.
Published: (2025-01-01)

PHARMACOECONOMICAL RESEARCH OF THE USE OF SORAFENIB IN MALIGNANT TUMORS
by: M. Y. Frolov, et al.
Published: (2016-09-01)

Exploring anti-cancer activities of epidermal growth factor-immobilized polymeric nanoparticles
by: Shota Yamamoto, et al.
Published: (2025-02-01)

A comprehensive insight of innovations and recent advancements in nanocarriers for nose-to-brain drug targeting
by: Naeem Mubarak, et al.
Published: (2025-12-01)

CircTTC13 promotes sorafenib resistance in hepatocellular carcinoma through the inhibition of ferroptosis by targeting the miR-513a-5p/SLC7A11 axis
by: Ying Zhang, et al.
Published: (2025-01-01)

Tolerability and Effectiveness of Regorafenib Treatment in Patients with Unresectable Hepatocellular Carcinoma: Real-World Data from the United States
by: Finn RS, et al.
Published: (2025-02-01)

A systematic review of nanocarriers used in medicine and beyond — definition and categorization framework
by: Sabine Gressler, et al.
Published: (2025-02-01)

Dual targeting of breast cancer by chitosan/poly lactic-co-glycolic acid nanodelivery systems: Surface activation with folic acid/aptamers, and co-encapsulated with Sorafenib and quercetin
by: Asghar Narmani, et al.
Published: (2025-03-01)

(−)-Epigallocatechin-3-Gallate and Quercetin Inhibit Quiescin Sulfhydryl Oxidase 1 Secretion from Hepatocellular Carcinoma Cells
by: Lumin Yang, et al.
Published: (2025-01-01)

The Potential Application of Nanocarriers in Delivering Topical Antioxidants
by: Zulfan Zazuli, et al.
Published: (2025-01-01)

Hybrid Carbohydrate–Lipid Nanocarriers: In Vitro Efficacy Gene-Rated by Association of UV-Absorbers and Raspberry Polyphenols Rich-Fraction
by: Nicoleta Badea, et al.
Published: (2024-12-01)

Encapsulation of docosahexaenoic acid (DHA) using self-assembling food-derived proteins for efficient biological functions
by: Yumeng Liu, et al.
Published: (2023-09-01)

Innovative approaches to asthma treatment: harnessing nanoparticle technology
by: Vanshika Goswami, et al.
Published: (2025-02-01)

Optimizing glycerosome formulations via an orthogonal experimental design to enhance transdermal triptolide delivery
by: Zhu Chunyun, et al.
Published: (2022-03-01)

Nanoparticle-in-Hydrogel Delivery System for the Sequential Release of Two Drugs
by: Demian van Straten, et al.
Published: (2025-01-01)

Eco-Friendly Hydrogels Loading Polyphenols-Composed Biomimetic Micelles for Topical Administration of Resveratrol and Rutin
by: Beatriz N. Guedes, et al.
Published: (2024-12-01)

Various Sizes and Shapes of Mixed-Anion Fe(NH<sub>2</sub>trz)<sub>3</sub>(BF<sub>4</sub>)<sub>2−x</sub>(SiF<sub>6</sub>)<sub>x/2</sub>@SiO<sub>2</sub> Nanohybrid Particles Undergoing Spin Crossover Just Above Room Temperature
by: Xinyu Yang, et al.
Published: (2025-01-01)

Deep-insights: Nanoengineered gel-based localized drug delivery for arthritis management
by: Anitha Sriram, et al.
Published: (2025-02-01)

Dutasteride nanoemulsion preparation to inhibit 5‐alpha‐hair follicle reductase enzymes in the hair follicle; an ex vivo study
by: Mehri Memar Bashi Aval, et al.
Published: (2023-02-01)

Development of Spray-Dried Micelles, Liposomes, and Solid Lipid Nanoparticles for Enhanced Stability
by: Shradha Dattani, et al.
Published: (2025-01-01)

Selection strategy for encapsulation of hydrophilic and hydrophobic ingredients with food-grade materials: A systematic review and analysis
by: Ruihan Huang, et al.
Published: (2025-01-01)

A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine delivery
by: Elina E. Mansurova, et al.
Published: (2025-01-01)

From micro to macro, nanotechnology demystifies acute pancreatitis: a new generation of treatment options emerges
by: Wei Du, et al.
Published: (2025-01-01)

Nanostructured food proteins as efficient systems for the encapsulation of bioactive compounds
by: Mehdi Mohammadian, et al.
Published: (2020-09-01)

The Multifaceted Role of Extracellular Vesicles in Glioblastoma: microRNA Nanocarriers for Disease Progression and Gene Therapy
by: Natalia Simionescu, et al.
Published: (2021-06-01)

Kinetics of acryloyloxyethyl trimethyl ammonium chloride polymerization in aqueous solutions
by: Fu Xingqin, et al.
Published: (2025-01-01)

Nano‐gold micelles loaded Dox and Elacridar for reversing drug resistance of breast cancer
by: Liu‐Jing Wen, et al.
Published: (2023-04-01)

Treatment of rheumatoid arthritis using dual-targeted and dual-response intelligent micelles: a “three birds with one stone” strategy
by: Rui-Bo Guo, et al.
Published: (2025-02-01)

Peptide Antigen Modifications Influence the On-Target and Off-Target Antibody Response for an Influenza Subunit Vaccine
by: Megan C. Schulte, et al.
Published: (2025-01-01)

Co-Delivery of Dacarbazine and miRNA 34a Combinations to Synergistically Improve Malignant Melanoma Treatments
by: Ding B, et al.
Published: (2025-01-01)

Nano-delivery platform with strong protection and efficient delivery: preparation of self-assembled RNA pesticide with dual RNAi targets against Apolygus lucorum
by: Heng Qiao, et al.
Published: (2025-02-01)

Evaluation of Carboxymethyl-Hexanoyl Chitosan as a Protein Nanocarrier
by: Mikael Larsson, et al.
Published: (2013-06-01)

A ROS-responsive hydrogel encapsulated with matrix metalloproteinase-13 siRNA nanocarriers to attenuate osteoarthritis progression
by: Qiuyang Wang, et al.
Published: (2025-01-01)

Introduction to Polymer Chemistry /
by: Carraher, Charles E., Jr., 1941-
Published: (2017)