Epidemiology, Clinical Characteristics and Treatment Outcomes of Acinetobacter baumannii Infection at a Regional Hospital in Thailand
Parichart Sakulkonkij,1 Jackrapong Bruminhent2 1Division of Infectious Diseases, Internal Medicine Department, Lampang Hospital, Lampang, Thailand; 2Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence:...
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Dove Medical Press
2025-01-01
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| author | Sakulkonkij P Bruminhent J |
| author_facet | Sakulkonkij P Bruminhent J |
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| description | Parichart Sakulkonkij,1 Jackrapong Bruminhent2 1Division of Infectious Diseases, Internal Medicine Department, Lampang Hospital, Lampang, Thailand; 2Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Parichart Sakulkonkij, Division of Infectious Diseases, Internal Medicine Department, Lampang Hospital, Lampang, Thailand, Email parichart1507@gmail.comObjective: This retrospective cohort study evaluated the treatment outcome of Acinetobacter baumannii infection.Methods: In this retrospective cohort study, 476 patients with Acinetobacter baumannii (A. baumannii) infection who were admitted to the internal medicine ward at Lampang Hospital, Lampang, Thailand, from 1 January 2020 to 31 December 2020 were enrolled. Medical records were reviewed.Results: A total of 476 patients with A. baumannii infection were enrolled. Of these, 204 (43%) survived, while 272 (57%) died. Extensively drug-resistant (XDR) A. baumannii with hospital-acquired pneumonia was the most common presentation. Risk factors for acquiring multidrug-resistant (MDR) pathogens included previous hospitalization or antibiotic use and the presence of an indwelling urinary catheter, which was common in both survived and deceased groups. The survival group was significantly more likely to have received appropriate antibiotic therapy compared to the deceased group (71% vs 51%; p< 0.001), particularly with colistin monotherapy (34% vs 18%; p< 0.001). Additionally, multivariate analysis showed that predictors of unfavorable outcomes, such as multiorgan failure, hypoalbuminemia, hematologic malignancy, and healthcare-associated pneumonia. The survival group had a significantly longer hospital stay compared to the deceased group (15 days vs 7 days; p< 0.001) and also showed an increased microbiological cure rate (49% vs 26%; p< 0.001).Conclusion: XDR A. baumannii leads to serious nosocomial infections. Understanding the risk factors for XDR A. baumannii infections could enhance colistin prescription prior to the antimicrobial susceptibility testing results.Keywords: Acinetobacter baumannii infection, multidrug-resistant pathogens, clinical outcomes, microbiological outcomes |
| format | Article |
| id | doaj-art-bf10f533375e468a98ddfd79c208e5e1 |
| institution | Kabale University |
| issn | 1178-6973 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
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| series | Infection and Drug Resistance |
| spelling | doaj-art-bf10f533375e468a98ddfd79c208e5e12025-01-27T18:05:34ZengDove Medical PressInfection and Drug Resistance1178-69732025-01-01Volume 1847348299582Epidemiology, Clinical Characteristics and Treatment Outcomes of Acinetobacter baumannii Infection at a Regional Hospital in ThailandSakulkonkij PBruminhent JParichart Sakulkonkij,1 Jackrapong Bruminhent2 1Division of Infectious Diseases, Internal Medicine Department, Lampang Hospital, Lampang, Thailand; 2Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Parichart Sakulkonkij, Division of Infectious Diseases, Internal Medicine Department, Lampang Hospital, Lampang, Thailand, Email parichart1507@gmail.comObjective: This retrospective cohort study evaluated the treatment outcome of Acinetobacter baumannii infection.Methods: In this retrospective cohort study, 476 patients with Acinetobacter baumannii (A. baumannii) infection who were admitted to the internal medicine ward at Lampang Hospital, Lampang, Thailand, from 1 January 2020 to 31 December 2020 were enrolled. Medical records were reviewed.Results: A total of 476 patients with A. baumannii infection were enrolled. Of these, 204 (43%) survived, while 272 (57%) died. Extensively drug-resistant (XDR) A. baumannii with hospital-acquired pneumonia was the most common presentation. Risk factors for acquiring multidrug-resistant (MDR) pathogens included previous hospitalization or antibiotic use and the presence of an indwelling urinary catheter, which was common in both survived and deceased groups. The survival group was significantly more likely to have received appropriate antibiotic therapy compared to the deceased group (71% vs 51%; p< 0.001), particularly with colistin monotherapy (34% vs 18%; p< 0.001). Additionally, multivariate analysis showed that predictors of unfavorable outcomes, such as multiorgan failure, hypoalbuminemia, hematologic malignancy, and healthcare-associated pneumonia. The survival group had a significantly longer hospital stay compared to the deceased group (15 days vs 7 days; p< 0.001) and also showed an increased microbiological cure rate (49% vs 26%; p< 0.001).Conclusion: XDR A. baumannii leads to serious nosocomial infections. Understanding the risk factors for XDR A. baumannii infections could enhance colistin prescription prior to the antimicrobial susceptibility testing results.Keywords: Acinetobacter baumannii infection, multidrug-resistant pathogens, clinical outcomes, microbiological outcomeshttps://www.dovepress.com/epidemiology-clinical-characteristics-and-treatment-outcomes-of-acinet-peer-reviewed-fulltext-article-IDRacinetobacter baumannii infectionmultidrug-resistant pathogensclinical outcomesmicrobiological outcomes |
| spellingShingle | Sakulkonkij P Bruminhent J Epidemiology, Clinical Characteristics and Treatment Outcomes of Acinetobacter baumannii Infection at a Regional Hospital in Thailand Infection and Drug Resistance acinetobacter baumannii infection multidrug-resistant pathogens clinical outcomes microbiological outcomes |
| title | Epidemiology, Clinical Characteristics and Treatment Outcomes of Acinetobacter baumannii Infection at a Regional Hospital in Thailand |
| title_full | Epidemiology, Clinical Characteristics and Treatment Outcomes of Acinetobacter baumannii Infection at a Regional Hospital in Thailand |
| title_fullStr | Epidemiology, Clinical Characteristics and Treatment Outcomes of Acinetobacter baumannii Infection at a Regional Hospital in Thailand |
| title_full_unstemmed | Epidemiology, Clinical Characteristics and Treatment Outcomes of Acinetobacter baumannii Infection at a Regional Hospital in Thailand |
| title_short | Epidemiology, Clinical Characteristics and Treatment Outcomes of Acinetobacter baumannii Infection at a Regional Hospital in Thailand |
| title_sort | epidemiology clinical characteristics and treatment outcomes of acinetobacter baumannii infection at a regional hospital in thailand |
| topic | acinetobacter baumannii infection multidrug-resistant pathogens clinical outcomes microbiological outcomes |
| url | https://www.dovepress.com/epidemiology-clinical-characteristics-and-treatment-outcomes-of-acinet-peer-reviewed-fulltext-article-IDR |
| work_keys_str_mv | AT sakulkonkijp epidemiologyclinicalcharacteristicsandtreatmentoutcomesofacinetobacterbaumanniiinfectionataregionalhospitalinthailand AT bruminhentj epidemiologyclinicalcharacteristicsandtreatmentoutcomesofacinetobacterbaumanniiinfectionataregionalhospitalinthailand |