Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction
The aim of the study was to evaluate whether obstructive sleep apnea (OSA) contributes directly to left ventricular (LV) diastolic and regional systolic dysfunction in newly diagnosed OSA with normal left ventricle ejection fraction. Methods. 125 consecutive patients were prospectively enrolled in t...
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| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/898746 |
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| author | Lisulov Popovic Danica Mirjana Krotin Marija Zdravkovic Ivan Soldatovic Darko Zdravkovic Milica Brajkovic Vera Gardijan Jelena Saric Ruzica Pokrajac Dragan Lovic Predrag Stevanovic Milina Tancic Gajic Miodrag Vukcevic |
| author_facet | Lisulov Popovic Danica Mirjana Krotin Marija Zdravkovic Ivan Soldatovic Darko Zdravkovic Milica Brajkovic Vera Gardijan Jelena Saric Ruzica Pokrajac Dragan Lovic Predrag Stevanovic Milina Tancic Gajic Miodrag Vukcevic |
| author_sort | Lisulov Popovic Danica |
| collection | DOAJ |
| description | The aim of the study was to evaluate whether obstructive sleep apnea (OSA) contributes directly to left ventricular (LV) diastolic and regional systolic dysfunction in newly diagnosed OSA with normal left ventricle ejection fraction. Methods. 125 consecutive patients were prospectively enrolled in the study. Control group consisted of 78 asymptomatic age-matched healthy subjects who did not have any cardiovascular and respiratory diseases. All patients had undergone overnight polysomnography and standard transthoracic and tissue Doppler imaging echocardiogram. Results. The E/A ratio and the peak E wave at mitral flow were significantly lower and the peak A wave at mitral flow was significantly higher in OSA patients compared with control subjects. Left ventricle isovolumetric relaxation time (IVRT) and mitral valve flow propagation (MVFP) were significantly longer in OSA patients than in controls. Tissue Doppler derived S′ amplitude of lateral part at mitral valve (S′Lm) and E′ wave amplitudes both at the lateral (E′Lm) and septal parts of the mitral valve (E′Sm) were significantly lower in OSA patients compared to controls. Conclusion. Newly diagnosed OSA patients with normal global LV function have significantly impaired diastolic function and regional longitudinal systolic function. OSA is independently associated with these changes in LV function. |
| format | Article |
| id | doaj-art-bf00be143bee44f786ec2942b7774e20 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-bf00be143bee44f786ec2942b7774e202025-02-03T01:20:57ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/898746898746Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection FractionLisulov Popovic Danica0Mirjana Krotin1Marija Zdravkovic2Ivan Soldatovic3Darko Zdravkovic4Milica Brajkovic5Vera Gardijan6Jelena Saric7Ruzica Pokrajac8Dragan Lovic9Predrag Stevanovic10Milina Tancic Gajic11Miodrag Vukcevic12University Clinical Hospital Center Bezanijska Kosa, Faculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaUniversity Clinical Hospital Center Bezanijska Kosa, Faculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaUniversity Clinical Hospital Center Bezanijska Kosa, Faculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaInstitute for Biomedical Statistics, Faculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaUniversity Clinical Hospital Center Bezanijska Kosa, Faculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaUniversity Clinical Hospital Center Bezanijska Kosa, Faculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaUniversity Clinical Hospital Center Bezanijska Kosa, Faculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaUniversity Clinical Hospital Center Bezanijska Kosa, Faculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaUniversity Clinical Hospital Center Bezanijska Kosa, Faculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaClinic for Internal Disease Intermedica, 18000 Nis, SerbiaUniversity Clinical Hospital Center Bezanijska Kosa, Faculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaInstitute for Endocrinology, Metabolic Disease and Obesity, Faculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaUniversity Clinical Hospital Center Bezanijska Kosa, Faculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaThe aim of the study was to evaluate whether obstructive sleep apnea (OSA) contributes directly to left ventricular (LV) diastolic and regional systolic dysfunction in newly diagnosed OSA with normal left ventricle ejection fraction. Methods. 125 consecutive patients were prospectively enrolled in the study. Control group consisted of 78 asymptomatic age-matched healthy subjects who did not have any cardiovascular and respiratory diseases. All patients had undergone overnight polysomnography and standard transthoracic and tissue Doppler imaging echocardiogram. Results. The E/A ratio and the peak E wave at mitral flow were significantly lower and the peak A wave at mitral flow was significantly higher in OSA patients compared with control subjects. Left ventricle isovolumetric relaxation time (IVRT) and mitral valve flow propagation (MVFP) were significantly longer in OSA patients than in controls. Tissue Doppler derived S′ amplitude of lateral part at mitral valve (S′Lm) and E′ wave amplitudes both at the lateral (E′Lm) and septal parts of the mitral valve (E′Sm) were significantly lower in OSA patients compared to controls. Conclusion. Newly diagnosed OSA patients with normal global LV function have significantly impaired diastolic function and regional longitudinal systolic function. OSA is independently associated with these changes in LV function.http://dx.doi.org/10.1155/2014/898746 |
| spellingShingle | Lisulov Popovic Danica Mirjana Krotin Marija Zdravkovic Ivan Soldatovic Darko Zdravkovic Milica Brajkovic Vera Gardijan Jelena Saric Ruzica Pokrajac Dragan Lovic Predrag Stevanovic Milina Tancic Gajic Miodrag Vukcevic Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction The Scientific World Journal |
| title | Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction |
| title_full | Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction |
| title_fullStr | Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction |
| title_full_unstemmed | Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction |
| title_short | Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction |
| title_sort | early left ventricular systolic and diastolic dysfunction in patients with newly diagnosed obstructive sleep apnoea and normal left ventricular ejection fraction |
| url | http://dx.doi.org/10.1155/2014/898746 |
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