Targeting LHPP in neoadjuvant chemotherapy resistance of gastric cancer: insights from single-cell and multi-omics data on tumor immune microenvironment and stemness characteristics

Targeting LHPP in neoadjuvant chemotherapy resistance of gastric cancer: insights from single-cell and multi-omics data on tumor immune microenvironment and stemness characteristics

Abstract Gastric cancer (GC) is a highly heterogeneous and complex malignancy, often characterized by tumor stemness and immune evasion mechanisms, which contribute to a poor response to neoadjuvant chemotherapy (NAC) and treatment resistance. In this study, we performed a comprehensive analysis usi...

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Bibliographic Details
Main Authors: You-Xin Gao, Xiao-Jing Guo, Bin Lin, Xiao-Bo Huang, Ru-Hong Tu, Mi Lin, Long-Long Cao, Qi-Yue Chen, Jia-Bin Wang, Jian-Wei Xie, Ping Li, Chao-Hui Zheng, Ying-Hong Yang, Chang-Ming Huang, Jian-Xian Lin
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07614-z
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