Effect of high-flow nasal therapy on patient-centred outcomes in patients at high risk of postoperative pulmonary complications after cardiac surgery: update to the statistical analysis plan for NOTACS, a multicentre adaptive randomised controlled trial

Effect of high-flow nasal therapy on patient-centred outcomes in patients at high risk of postoperative pulmonary complications after cardiac surgery: update to the statistical analysis plan for NOTACS, a multicentre adaptive randomised controlled trial

Abstract Background The NOTACS trial will assess the efficacy, safety and cost-effectiveness of high-flow nasal therapy (HFNT) compared to standard oxygen therapy (SOT) on the outcomes of patients after cardiac surgery. Methods/design NOTACS is an adaptive, international, multicentre, parallel group...

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Bibliographic Details
Main Authors: Sarah N. Dawson, Yi-Da Chiu, Andrew A. Klein, Melissa Earwaker, Sofia S. Villar, on behalf of the NOTACS study team
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Trials
Subjects:
Statistical analysis plan
Adaptive design
Sample size re-estimation
Online Access:https://doi.org/10.1186/s13063-024-08538-3
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