Cardiac Function in Long-Term Survivors of Childhood Lymphoma
Objectives. We studied long-term effects of therapy for childhood lymphoma on cardiac function. Design and patients. We prospectively evaluated 45 survivors of childhood lymphoma, using clinical parameters, electrocardiography and echocardiography. Further comparisons were made between lymphoma subg...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.4061/2011/316927 |
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| author | Mark K. Friedberg Ido Solt Myriam Weyl-Ben-Arush Yulia Braver Avraham Lorber |
| author_facet | Mark K. Friedberg Ido Solt Myriam Weyl-Ben-Arush Yulia Braver Avraham Lorber |
| author_sort | Mark K. Friedberg |
| collection | DOAJ |
| description | Objectives. We studied long-term effects of therapy for childhood lymphoma on cardiac function. Design and patients. We prospectively evaluated 45 survivors of childhood lymphoma, using clinical parameters, electrocardiography and echocardiography. Further comparisons were made between lymphoma subgroups and between males and females. Results. Mean age at diagnosis was 9.1 years. Mean followup duration was 10.9 years. The NYHA functional class was I in 43 patients and II in 2 patients. A prolonged QTc interval (>0.44 msec) was found in 8 patients. Left ventricular (LV) systolic function and compliance were normal (LV shortening fraction 40±5.6%; cardiac index 2.84±1.13
L/min/m2; E/A wave ratio 2.5±1.3; mean ± S.D.), LV mass was normal (97±40 grams/m2, mean ± S.D.). Mitral regurgitation was observed in 7/45 patients (16%). Asymptomatic pericardial effusions were found in 3/45 (7%) patients. Conclusions. Long-term follow-up shows that most parameters of cardiac function are normal in survivors of childhood lymphoma. This is likely due to relatively low doses of anthracyclines in modern protocol modalities. Abnormalities in mitral valve flow, QTc prolongation and in a small proportion of survivors, and functional capacity necessitate long-term cardiac follow-up of these patients. |
| format | Article |
| id | doaj-art-beecc4e2ac694ddf87de874c00458071 |
| institution | Kabale University |
| issn | 2090-0597 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-beecc4e2ac694ddf87de874c004580712025-02-03T05:46:17ZengWileyCardiology Research and Practice2090-05972011-01-01201110.4061/2011/316927316927Cardiac Function in Long-Term Survivors of Childhood LymphomaMark K. Friedberg0Ido Solt1Myriam Weyl-Ben-Arush2Yulia Braver3Avraham Lorber4Department of Pediatrics, Meyer Children's Hospital, Rambam Medical Center, Technion-Israel Institute of Technology, Haifa 31096, IsraelDivision of Obstetrics and Gynecology, Meyer Children's Hospital, Rambam Medical Center, Technion-Israel Institute of Technology, Haifa 31096, IsraelDepartment of Pediatric Hematology and Oncology, Meyer Children's Hospital, Rambam Medical Center, Technion-Israel Institute of Technology, Haifa 31096, IsraelUnit of Pediatric Cardiology, Meyer Children's Hospital, Rambam Medical Center, Technion-Israel Institute of Technology, Haifa, 31096, IsraelUnit of Pediatric Cardiology, Meyer Children's Hospital, Rambam Medical Center, Technion-Israel Institute of Technology, Haifa, 31096, IsraelObjectives. We studied long-term effects of therapy for childhood lymphoma on cardiac function. Design and patients. We prospectively evaluated 45 survivors of childhood lymphoma, using clinical parameters, electrocardiography and echocardiography. Further comparisons were made between lymphoma subgroups and between males and females. Results. Mean age at diagnosis was 9.1 years. Mean followup duration was 10.9 years. The NYHA functional class was I in 43 patients and II in 2 patients. A prolonged QTc interval (>0.44 msec) was found in 8 patients. Left ventricular (LV) systolic function and compliance were normal (LV shortening fraction 40±5.6%; cardiac index 2.84±1.13 L/min/m2; E/A wave ratio 2.5±1.3; mean ± S.D.), LV mass was normal (97±40 grams/m2, mean ± S.D.). Mitral regurgitation was observed in 7/45 patients (16%). Asymptomatic pericardial effusions were found in 3/45 (7%) patients. Conclusions. Long-term follow-up shows that most parameters of cardiac function are normal in survivors of childhood lymphoma. This is likely due to relatively low doses of anthracyclines in modern protocol modalities. Abnormalities in mitral valve flow, QTc prolongation and in a small proportion of survivors, and functional capacity necessitate long-term cardiac follow-up of these patients.http://dx.doi.org/10.4061/2011/316927 |
| spellingShingle | Mark K. Friedberg Ido Solt Myriam Weyl-Ben-Arush Yulia Braver Avraham Lorber Cardiac Function in Long-Term Survivors of Childhood Lymphoma Cardiology Research and Practice |
| title | Cardiac Function in Long-Term Survivors of Childhood Lymphoma |
| title_full | Cardiac Function in Long-Term Survivors of Childhood Lymphoma |
| title_fullStr | Cardiac Function in Long-Term Survivors of Childhood Lymphoma |
| title_full_unstemmed | Cardiac Function in Long-Term Survivors of Childhood Lymphoma |
| title_short | Cardiac Function in Long-Term Survivors of Childhood Lymphoma |
| title_sort | cardiac function in long term survivors of childhood lymphoma |
| url | http://dx.doi.org/10.4061/2011/316927 |
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