Antral Brushings and Biopsies for Gastric Campylobacter pylori: A Comparative Study of a Rapid Urease Test, Culture and Histology
A prospective study was conducted to assess the sensitivity and specificity of diagnostic tests for Campylobacter pylori in 60 unselected patients referred for gastroscopy. Urease testing was performed on samples of gastric mucus obtained by a disposable cytology brush and on gastric mucosal biopsie...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1989-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1989/914374 |
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| _version_ | 1832563314973999104 |
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| author | Howard M. Estrin Medhat O. Hassan Howard S. Carr Steven J. Czinn |
| author_facet | Howard M. Estrin Medhat O. Hassan Howard S. Carr Steven J. Czinn |
| author_sort | Howard M. Estrin |
| collection | DOAJ |
| description | A prospective study was conducted to assess the sensitivity and
specificity of diagnostic tests for Campylobacter pylori in 60 unselected patients
referred for gastroscopy. Urease testing was performed on samples of gastric mucus
obtained by a disposable cytology brush and on gastric mucosal biopsies. The
combination of the brush urease test and biopsy urease test had a sensitivity of
78% and a specificity of 96%. The combination of the brush urease test and examination
of gastric biopsies for curved bacilli had a sensitivity of 96% and a specificity
of 96%. The combination of the brush urease and biopsy urease tests will
rapidly identify the majority of patients with C pylori. This test is rapid, easy,
sensitive and inexpensive. If a pathologist is available, the addition of histologic
review for C pylori in combination with the brush urease test, will identify virtually
all patients with C pylori without the need for culturing this fastidious organism. |
| format | Article |
| id | doaj-art-bede573fb611473793ab9b5faf5509d3 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1989-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-bede573fb611473793ab9b5faf5509d32025-02-03T01:20:30ZengWileyCanadian Journal of Gastroenterology0835-79001989-01-0133919410.1155/1989/914374Antral Brushings and Biopsies for Gastric Campylobacter pylori: A Comparative Study of a Rapid Urease Test, Culture and HistologyHoward M. Estrin0Medhat O. Hassan1Howard S. Carr2Steven J. Czinn3Gastroenterology Section and the Department of Pathology, Cleveland Veterans Administration Medical Center, Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, Ohio, USAGastroenterology Section and the Department of Pathology, Cleveland Veterans Administration Medical Center, Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, Ohio, USAGastroenterology Section and the Department of Pathology, Cleveland Veterans Administration Medical Center, Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, Ohio, USAGastroenterology Section and the Department of Pathology, Cleveland Veterans Administration Medical Center, Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, Ohio, USAA prospective study was conducted to assess the sensitivity and specificity of diagnostic tests for Campylobacter pylori in 60 unselected patients referred for gastroscopy. Urease testing was performed on samples of gastric mucus obtained by a disposable cytology brush and on gastric mucosal biopsies. The combination of the brush urease test and biopsy urease test had a sensitivity of 78% and a specificity of 96%. The combination of the brush urease test and examination of gastric biopsies for curved bacilli had a sensitivity of 96% and a specificity of 96%. The combination of the brush urease and biopsy urease tests will rapidly identify the majority of patients with C pylori. This test is rapid, easy, sensitive and inexpensive. If a pathologist is available, the addition of histologic review for C pylori in combination with the brush urease test, will identify virtually all patients with C pylori without the need for culturing this fastidious organism.http://dx.doi.org/10.1155/1989/914374 |
| spellingShingle | Howard M. Estrin Medhat O. Hassan Howard S. Carr Steven J. Czinn Antral Brushings and Biopsies for Gastric Campylobacter pylori: A Comparative Study of a Rapid Urease Test, Culture and Histology Canadian Journal of Gastroenterology |
| title | Antral Brushings and Biopsies for Gastric Campylobacter pylori: A Comparative Study of a Rapid Urease Test, Culture and Histology |
| title_full | Antral Brushings and Biopsies for Gastric Campylobacter pylori: A Comparative Study of a Rapid Urease Test, Culture and Histology |
| title_fullStr | Antral Brushings and Biopsies for Gastric Campylobacter pylori: A Comparative Study of a Rapid Urease Test, Culture and Histology |
| title_full_unstemmed | Antral Brushings and Biopsies for Gastric Campylobacter pylori: A Comparative Study of a Rapid Urease Test, Culture and Histology |
| title_short | Antral Brushings and Biopsies for Gastric Campylobacter pylori: A Comparative Study of a Rapid Urease Test, Culture and Histology |
| title_sort | antral brushings and biopsies for gastric campylobacter pylori a comparative study of a rapid urease test culture and histology |
| url | http://dx.doi.org/10.1155/1989/914374 |
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