Antral Brushings and Biopsies for Gastric Campylobacter pylori: A Comparative Study of a Rapid Urease Test, Culture and Histology
A prospective study was conducted to assess the sensitivity and specificity of diagnostic tests for Campylobacter pylori in 60 unselected patients referred for gastroscopy. Urease testing was performed on samples of gastric mucus obtained by a disposable cytology brush and on gastric mucosal biopsie...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1989-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1989/914374 |
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| Summary: | A prospective study was conducted to assess the sensitivity and
specificity of diagnostic tests for Campylobacter pylori in 60 unselected patients
referred for gastroscopy. Urease testing was performed on samples of gastric mucus
obtained by a disposable cytology brush and on gastric mucosal biopsies. The
combination of the brush urease test and biopsy urease test had a sensitivity of
78% and a specificity of 96%. The combination of the brush urease test and examination
of gastric biopsies for curved bacilli had a sensitivity of 96% and a specificity
of 96%. The combination of the brush urease and biopsy urease tests will
rapidly identify the majority of patients with C pylori. This test is rapid, easy,
sensitive and inexpensive. If a pathologist is available, the addition of histologic
review for C pylori in combination with the brush urease test, will identify virtually
all patients with C pylori without the need for culturing this fastidious organism. |
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| ISSN: | 0835-7900 |