The inflammasome adaptor protein ASC promotes amyloid deposition in cryopyrin-associated periodic syndromes
In this Correspondence, P. Pelegrin and colleagues found that the deposition of amyloid in tissues in Cryopyrin-Associated Periodic Syndrome were promoted by the extracellular presence of the inflammasome adaptor protein ASC, opening exciting new directions in clinical practice to obtain a novel the...
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| Format: | Article |
| Language: | English |
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Springer Nature
2024-12-01
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| Series: | EMBO Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s44321-024-00176-1 |
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| author | Cristina Alarcón-Vila Laura Hurtado-Navarro Sandra V Mateo Alejandro Peñín-Franch Carlos M Martínez Cristina Molina-López María C Baños Ana I Gómez Javier Gómez-Román Alberto Baroja-Mazo Juan I Arostegui Natalia Palmou-Fontana Juan J Martínez-García Pablo Pelegrin |
| author_facet | Cristina Alarcón-Vila Laura Hurtado-Navarro Sandra V Mateo Alejandro Peñín-Franch Carlos M Martínez Cristina Molina-López María C Baños Ana I Gómez Javier Gómez-Román Alberto Baroja-Mazo Juan I Arostegui Natalia Palmou-Fontana Juan J Martínez-García Pablo Pelegrin |
| author_sort | Cristina Alarcón-Vila |
| collection | DOAJ |
| description | In this Correspondence, P. Pelegrin and colleagues found that the deposition of amyloid in tissues in Cryopyrin-Associated Periodic Syndrome were promoted by the extracellular presence of the inflammasome adaptor protein ASC, opening exciting new directions in clinical practice to obtain a novel therapy towards secondary amyloidosis in inflammasomopathies. |
| format | Article |
| id | doaj-art-bedcada951274a02a92ce7ccae66e203 |
| institution | Kabale University |
| issn | 1757-4684 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-bedcada951274a02a92ce7ccae66e2032025-01-19T12:34:37ZengSpringer NatureEMBO Molecular Medicine1757-46842024-12-01171415310.1038/s44321-024-00176-1The inflammasome adaptor protein ASC promotes amyloid deposition in cryopyrin-associated periodic syndromesCristina Alarcón-Vila0Laura Hurtado-Navarro1Sandra V Mateo2Alejandro Peñín-Franch3Carlos M Martínez4Cristina Molina-López5María C Baños6Ana I Gómez7Javier Gómez-Román8Alberto Baroja-Mazo9Juan I Arostegui10Natalia Palmou-Fontana11Juan J Martínez-García12Pablo Pelegrin13Molecular Inflammation Group, Biomedical Research Institute of Murcia (IMIB)Molecular Inflammation Group, Biomedical Research Institute of Murcia (IMIB)Molecular Inflammation Group, Biomedical Research Institute of Murcia (IMIB)Molecular Inflammation Group, Biomedical Research Institute of Murcia (IMIB)Molecular Inflammation Group, Biomedical Research Institute of Murcia (IMIB)Molecular Inflammation Group, Biomedical Research Institute of Murcia (IMIB)Molecular Inflammation Group, Biomedical Research Institute of Murcia (IMIB)Molecular Inflammation Group, Biomedical Research Institute of Murcia (IMIB)Anatomical Pathology Service, Marqués de Valdecilla University Hospital-IDIVAL, University of CantabriaMolecular Inflammation Group, Biomedical Research Institute of Murcia (IMIB)Department of Immunology, Hospital ClínicRheumatology Service, Immunopathology Group, Marqués de Valdecilla University Hospital-IDIVALMolecular Inflammation Group, Biomedical Research Institute of Murcia (IMIB)Molecular Inflammation Group, Biomedical Research Institute of Murcia (IMIB)In this Correspondence, P. Pelegrin and colleagues found that the deposition of amyloid in tissues in Cryopyrin-Associated Periodic Syndrome were promoted by the extracellular presence of the inflammasome adaptor protein ASC, opening exciting new directions in clinical practice to obtain a novel therapy towards secondary amyloidosis in inflammasomopathies.https://doi.org/10.1038/s44321-024-00176-1 |
| spellingShingle | Cristina Alarcón-Vila Laura Hurtado-Navarro Sandra V Mateo Alejandro Peñín-Franch Carlos M Martínez Cristina Molina-López María C Baños Ana I Gómez Javier Gómez-Román Alberto Baroja-Mazo Juan I Arostegui Natalia Palmou-Fontana Juan J Martínez-García Pablo Pelegrin The inflammasome adaptor protein ASC promotes amyloid deposition in cryopyrin-associated periodic syndromes EMBO Molecular Medicine |
| title | The inflammasome adaptor protein ASC promotes amyloid deposition in cryopyrin-associated periodic syndromes |
| title_full | The inflammasome adaptor protein ASC promotes amyloid deposition in cryopyrin-associated periodic syndromes |
| title_fullStr | The inflammasome adaptor protein ASC promotes amyloid deposition in cryopyrin-associated periodic syndromes |
| title_full_unstemmed | The inflammasome adaptor protein ASC promotes amyloid deposition in cryopyrin-associated periodic syndromes |
| title_short | The inflammasome adaptor protein ASC promotes amyloid deposition in cryopyrin-associated periodic syndromes |
| title_sort | inflammasome adaptor protein asc promotes amyloid deposition in cryopyrin associated periodic syndromes |
| url | https://doi.org/10.1038/s44321-024-00176-1 |
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