Impaired fracture healing is associated with callus chondro-osseous junction abnormalities in periostin-null and osteopontin-null mice

Impaired fracture healing is associated with callus chondro-osseous junction abnormalities in periostin-null and osteopontin-null mice

Periostin and osteopontin are matricellular proteins abundantly expressed in bone fracture callus. Null mutation of either the periostin (Postn) gene or the osteopontin (Spp1) gene can impair bone fracture healing. However, the cell and molecular pathways affected by loss of POSTN or SPP1 which lead...

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Bibliographic Details
Main Authors: Marc Teitelbaum, Maya D. Culbertson, Charlene Wetterstrand, J. Patrick O’Connor
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Experimental Biology and Medicine
Subjects:
periostin
osteopontin
endochondral ossification
chondro-osseous junction
fracture healing
osteoclast
Online Access:https://www.ebm-journal.org/articles/10.3389/ebm.2024.10066/full
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