Peritoneal lavage with sterile water reduces IL-1 levels and postoperative adhesions following laparotomy in rats
Peritoneal lavage with normal saline is common in abdominal surgeries, yet recent studies indicate that it increases intraperitoneal adhesion risks. This study compares the effects of peritoneal lavage with normal saline versus sterile water on interleukin-1 (IL-1) levels and intraperitoneal adhesio...
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Universitas Sultan Agung Semarang
2024-06-01
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| Series: | Sains Medika |
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| Online Access: | https://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/36698 |
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| author | Ryan Fernandi I Ketut Sudartana Made Agus Dwianthara Sueta I Made Mahayasa Ketut Putu Yasa I Gusti Agung Bagus Krisna Wibawa |
| author_facet | Ryan Fernandi I Ketut Sudartana Made Agus Dwianthara Sueta I Made Mahayasa Ketut Putu Yasa I Gusti Agung Bagus Krisna Wibawa |
| author_sort | Ryan Fernandi |
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| description | Peritoneal lavage with normal saline is common in abdominal surgeries, yet recent studies indicate that it increases intraperitoneal adhesion risks. This study compares the effects of peritoneal lavage with normal saline versus sterile water on interleukin-1 (IL-1) levels and intraperitoneal adhesion following laparotomy in rats. In this post-test control group study, 20 adult Wistar rats were subjected to laparotomy before being randomly divided into two groups to receive either intraperitoneal lavage with normal saline (0.9% NaCl) or sterile water. After 7 days, IL-1 level and degree of adhesion were evaluated. The saline group had higher adhesion levels (4 rats with grade 4, 5 with grade 3, 1 with grade 2) than the sterile water group, which had lower levels (2 rats with grade 3, 5 with grade 2, 3 with grade 1). There was a significant difference in IL-1 levels between the sterile water group (37,111.6 ± 6,535.61 pg/ml) and the normal saline group (57,456.3 ± 10,583.41 pg/ml). There was a significant correlation between IL-1 levels and adhesion grade (p=0.008). Intraperitoneal lavage with sterile water results in significantly lower adhesion grade and IL-1 levels than normal saline, suggesting its potential for reducing postoperative adhesions. Further studies are needed to elucidate the mechanism of reduced adhesion and inflammation associated with sterile water lavage. |
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| institution | Kabale University |
| issn | 2085-1545 2339-093X |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Universitas Sultan Agung Semarang |
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| spelling | doaj-art-becd865908bd4974a6812ae76fd5050b2025-02-03T08:04:20ZengUniversitas Sultan Agung SemarangSains Medika2085-15452339-093X2024-06-01151212710.30659/sainsmed.v15i1.366989957Peritoneal lavage with sterile water reduces IL-1 levels and postoperative adhesions following laparotomy in ratsRyan Fernandi0I Ketut Sudartana1Made Agus Dwianthara Sueta2I Made Mahayasa3Ketut Putu Yasa4I Gusti Agung Bagus Krisna Wibawa5Department of Surgery, Faculty of Medicine, Udayana University, Bali, Indonesia, Prof. Dr. IGNG Ngoerah General Hospital, DenpasarDigestive Surgery Division, Department of Surgery, Faculty of Medicine, Udayana University, BaliDigestive Surgery Division, Department of Surgery, Faculty of Medicine, Udayana University, BaliDigestive Surgery Division, Department of Surgery, Faculty of Medicine, Udayana University, BaliCardio Thoracic and Vascular Surgery Division, Department of Surgery, Faculty of Medicine, Udayana University, BaliVascular and Endovascular Surgery Division, Department of Surgery, Faculty of Medicine, Udayana University, BaliPeritoneal lavage with normal saline is common in abdominal surgeries, yet recent studies indicate that it increases intraperitoneal adhesion risks. This study compares the effects of peritoneal lavage with normal saline versus sterile water on interleukin-1 (IL-1) levels and intraperitoneal adhesion following laparotomy in rats. In this post-test control group study, 20 adult Wistar rats were subjected to laparotomy before being randomly divided into two groups to receive either intraperitoneal lavage with normal saline (0.9% NaCl) or sterile water. After 7 days, IL-1 level and degree of adhesion were evaluated. The saline group had higher adhesion levels (4 rats with grade 4, 5 with grade 3, 1 with grade 2) than the sterile water group, which had lower levels (2 rats with grade 3, 5 with grade 2, 3 with grade 1). There was a significant difference in IL-1 levels between the sterile water group (37,111.6 ± 6,535.61 pg/ml) and the normal saline group (57,456.3 ± 10,583.41 pg/ml). There was a significant correlation between IL-1 levels and adhesion grade (p=0.008). Intraperitoneal lavage with sterile water results in significantly lower adhesion grade and IL-1 levels than normal saline, suggesting its potential for reducing postoperative adhesions. Further studies are needed to elucidate the mechanism of reduced adhesion and inflammation associated with sterile water lavage.https://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/36698peritoneal lavagegrade of adhesionil-1sterile waternormal saline |
| spellingShingle | Ryan Fernandi I Ketut Sudartana Made Agus Dwianthara Sueta I Made Mahayasa Ketut Putu Yasa I Gusti Agung Bagus Krisna Wibawa Peritoneal lavage with sterile water reduces IL-1 levels and postoperative adhesions following laparotomy in rats Sains Medika peritoneal lavage grade of adhesion il-1 sterile water normal saline |
| title | Peritoneal lavage with sterile water reduces IL-1 levels and postoperative adhesions following laparotomy in rats |
| title_full | Peritoneal lavage with sterile water reduces IL-1 levels and postoperative adhesions following laparotomy in rats |
| title_fullStr | Peritoneal lavage with sterile water reduces IL-1 levels and postoperative adhesions following laparotomy in rats |
| title_full_unstemmed | Peritoneal lavage with sterile water reduces IL-1 levels and postoperative adhesions following laparotomy in rats |
| title_short | Peritoneal lavage with sterile water reduces IL-1 levels and postoperative adhesions following laparotomy in rats |
| title_sort | peritoneal lavage with sterile water reduces il 1 levels and postoperative adhesions following laparotomy in rats |
| topic | peritoneal lavage grade of adhesion il-1 sterile water normal saline |
| url | https://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/36698 |
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