Unmet needs of biochemical biomarkers for human prion diseases
Although the development of aggregation assays has noticeably improved the accuracy of the clinical diagnosis of prion diseases, research on biomarkers remains vital. The major challenges to overcome are non-invasive sampling and the exploration of new biomarkers that may predict the onset or reflec...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Prion |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19336896.2024.2349017 |
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| _version_ | 1832096699512782848 |
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| author | Peter Hermann Inga Zerr |
| author_facet | Peter Hermann Inga Zerr |
| author_sort | Peter Hermann |
| collection | DOAJ |
| description | Although the development of aggregation assays has noticeably improved the accuracy of the clinical diagnosis of prion diseases, research on biomarkers remains vital. The major challenges to overcome are non-invasive sampling and the exploration of new biomarkers that may predict the onset or reflect disease progression. This will become extremely important in the near future, when new therapeutics are clinically evaluated and eventually become available for treatment. This article aims to provide an overview of the achievements of biomarker research in human prion diseases, addresses unmet needs in the field, and points out future perspectives. |
| format | Article |
| id | doaj-art-becb1ff6dfbc40d48d532a58f376f7e4 |
| institution | Kabale University |
| issn | 1933-6896 1933-690X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Prion |
| spelling | doaj-art-becb1ff6dfbc40d48d532a58f376f7e42025-02-05T12:40:51ZengTaylor & Francis GroupPrion1933-68961933-690X2024-12-01181899310.1080/19336896.2024.2349017Unmet needs of biochemical biomarkers for human prion diseasesPeter Hermann0Inga Zerr1Department of Neurology, University Medical Center Göttingen, Göttingen, GermanyDepartment of Neurology, University Medical Center Göttingen, Göttingen, GermanyAlthough the development of aggregation assays has noticeably improved the accuracy of the clinical diagnosis of prion diseases, research on biomarkers remains vital. The major challenges to overcome are non-invasive sampling and the exploration of new biomarkers that may predict the onset or reflect disease progression. This will become extremely important in the near future, when new therapeutics are clinically evaluated and eventually become available for treatment. This article aims to provide an overview of the achievements of biomarker research in human prion diseases, addresses unmet needs in the field, and points out future perspectives.https://www.tandfonline.com/doi/10.1080/19336896.2024.2349017Biomarkerscerebrospinal fluid biomarkersCreutzfeldt-Jakob diseasediagnosisdisease onsetprion diseases |
| spellingShingle | Peter Hermann Inga Zerr Unmet needs of biochemical biomarkers for human prion diseases Prion Biomarkers cerebrospinal fluid biomarkers Creutzfeldt-Jakob disease diagnosis disease onset prion diseases |
| title | Unmet needs of biochemical biomarkers for human prion diseases |
| title_full | Unmet needs of biochemical biomarkers for human prion diseases |
| title_fullStr | Unmet needs of biochemical biomarkers for human prion diseases |
| title_full_unstemmed | Unmet needs of biochemical biomarkers for human prion diseases |
| title_short | Unmet needs of biochemical biomarkers for human prion diseases |
| title_sort | unmet needs of biochemical biomarkers for human prion diseases |
| topic | Biomarkers cerebrospinal fluid biomarkers Creutzfeldt-Jakob disease diagnosis disease onset prion diseases |
| url | https://www.tandfonline.com/doi/10.1080/19336896.2024.2349017 |
| work_keys_str_mv | AT peterhermann unmetneedsofbiochemicalbiomarkersforhumanpriondiseases AT ingazerr unmetneedsofbiochemicalbiomarkersforhumanpriondiseases |