Comparison of clinical efficacy and secondary infections between conventional-dose and high-dose glucocorticoid in hemorrhagic fever with renal syndrome: a dual-center retrospective cohort study

Comparison of clinical efficacy and secondary infections between conventional-dose and high-dose glucocorticoid in hemorrhagic fever with renal syndrome: a dual-center retrospective cohort study

Abstract Background Glucocorticoids (GC) are commonly administered during the febrile and hypotensive phases of hemorrhagic fever with renal syndrome (HFRS) to alleviate inflammation and capillary leakage. However, clinical dosing regimens show marked variability. This study aims to evaluate the cli...

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Main Authors: Denghui Yu, Jiayi Zhan, Hong Du, Pingping Zhu, Haifeng Hu, Hongkai Xu, Ludan Zhang, Fei Hu, Zhanhu Bi, Xiaofei Yang, Yanping Li, Jianqi Lian
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Infectious Diseases
Subjects:
Hemorrhagic fever with renal syndrome
Glucocorticoids
Clinical efficacy
Secondary infections
Propensity score matching
Online Access:https://doi.org/10.1186/s12879-025-11148-2
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