Cerium-based nanoplatform for severe acute pancreatitis: Achieving enhanced anti-inflammatory effects through calcium homeostasis restoration and oxidative stress mitigation
Severe acute pancreatitis (SAP), a life-threatening inflammatory disease of the pancreas, has a high mortality rate (∼40 %). Current therapeutic approaches, including antibiotics, trypsin inhibitors, fasting, rehydration, and even continuous renal replacement therapy, yield limited clinical manageme...
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Elsevier
2025-04-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S259000642500047X |
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| author | Tingyi Luo Yujing Tang Wangcheng Xie Zhilong Ma Jian Gong Yonggui Zhang Tingsong Yang Xuyang Jia Jia Zhou Zhengyu Hu Lin Han Qigang Wang Zhenshun Song |
| author_facet | Tingyi Luo Yujing Tang Wangcheng Xie Zhilong Ma Jian Gong Yonggui Zhang Tingsong Yang Xuyang Jia Jia Zhou Zhengyu Hu Lin Han Qigang Wang Zhenshun Song |
| author_sort | Tingyi Luo |
| collection | DOAJ |
| description | Severe acute pancreatitis (SAP), a life-threatening inflammatory disease of the pancreas, has a high mortality rate (∼40 %). Current therapeutic approaches, including antibiotics, trypsin inhibitors, fasting, rehydration, and even continuous renal replacement therapy, yield limited clinical management efficacy. Abnormally elevated calcium levels and reactive oxygen species (ROS) overproduction by damaged mitochondria are key factors in the inflammatory cascade in SAP. The combination of calcium chelators and cerium-based nanozymes loaded with catalase (MOF808@BA@CAT) was developed to bind intracellular calcium, eliminate excessive ROS, and ameliorate the resulting mitochondrial dysfunction, thereby achieving multiple anti-inflammatory effects on SAP. A single low dose of the nanoplatform (1.5 mg kg−1) significantly reduced pancreatic necrosis in SAP rats, effectively ameliorated oxidative stress in the pancreas, improved mitochondrial dysfunction, reduced the proportion of apoptotic cells, and blocked the systemic inflammatory amplification cascade, resulting in the alleviation of systemic inflammation. Moreover, the nanoplatform restored impaired autophagy and inhibited endoplasmic reticulum stress in pancreatic tissue, preserving injured acinar cells. Mechanistically, the administration of the nanoplatform reversed metabolic abnormalities in pancreatic tissue and inhibited the signaling pathways that promote inflammation progression in SAP. This nanoplatform provides a new strategy for SAP treatment, with clinical translation prospects, through ion homeostasis regulation and pancreatic oxidative stress inhibition. |
| format | Article |
| id | doaj-art-bec9196d4e5c423f8edf3cba9634419e |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-bec9196d4e5c423f8edf3cba9634419e2025-01-22T05:43:48ZengElsevierMaterials Today Bio2590-00642025-04-0131101489Cerium-based nanoplatform for severe acute pancreatitis: Achieving enhanced anti-inflammatory effects through calcium homeostasis restoration and oxidative stress mitigationTingyi Luo0Yujing Tang1Wangcheng Xie2Zhilong Ma3Jian Gong4Yonggui Zhang5Tingsong Yang6Xuyang Jia7Jia Zhou8Zhengyu Hu9Lin Han10Qigang Wang11Zhenshun Song12Department of Hepatobiliary and Pancreatic Surgery, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China; Department of Hepatobiliary and Pancreatic Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, ChinaSchool of Chemical Science and Engineering, Tongji University, Shanghai, 200092, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China; Department of Hepatobiliary and Pancreatic Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, ChinaDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, ChinaDepartment of Critical Care Medicine & Emergency, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 200030, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, ChinaDepartment of General Surgery, Tongren Hospital, School of Medicine, Jiaotong University, Shanghai, 200335, ChinaDepartment of Gastrointestinal and Hernia Surgery, The First Affiliated Hospital of Anhui Medical University, Anhui, 230000, ChinaCentral Laboratory, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, ChinaSchool of Chemical Science and Engineering, Tongji University, Shanghai, 200092, China; Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China; Corresponding author. School of Chemical Science and Engineering, Tongji University, Shanghai, 200092, China.Department of Hepatobiliary and Pancreatic Surgery, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China; Corresponding author. Department of Hepatobiliary and Pancreatic Surgery, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China.Severe acute pancreatitis (SAP), a life-threatening inflammatory disease of the pancreas, has a high mortality rate (∼40 %). Current therapeutic approaches, including antibiotics, trypsin inhibitors, fasting, rehydration, and even continuous renal replacement therapy, yield limited clinical management efficacy. Abnormally elevated calcium levels and reactive oxygen species (ROS) overproduction by damaged mitochondria are key factors in the inflammatory cascade in SAP. The combination of calcium chelators and cerium-based nanozymes loaded with catalase (MOF808@BA@CAT) was developed to bind intracellular calcium, eliminate excessive ROS, and ameliorate the resulting mitochondrial dysfunction, thereby achieving multiple anti-inflammatory effects on SAP. A single low dose of the nanoplatform (1.5 mg kg−1) significantly reduced pancreatic necrosis in SAP rats, effectively ameliorated oxidative stress in the pancreas, improved mitochondrial dysfunction, reduced the proportion of apoptotic cells, and blocked the systemic inflammatory amplification cascade, resulting in the alleviation of systemic inflammation. Moreover, the nanoplatform restored impaired autophagy and inhibited endoplasmic reticulum stress in pancreatic tissue, preserving injured acinar cells. Mechanistically, the administration of the nanoplatform reversed metabolic abnormalities in pancreatic tissue and inhibited the signaling pathways that promote inflammation progression in SAP. This nanoplatform provides a new strategy for SAP treatment, with clinical translation prospects, through ion homeostasis regulation and pancreatic oxidative stress inhibition.http://www.sciencedirect.com/science/article/pii/S259000642500047XSevere acute pancreatitisNanoplatformCalciumOxidative stressMitochondrial dysfunction |
| spellingShingle | Tingyi Luo Yujing Tang Wangcheng Xie Zhilong Ma Jian Gong Yonggui Zhang Tingsong Yang Xuyang Jia Jia Zhou Zhengyu Hu Lin Han Qigang Wang Zhenshun Song Cerium-based nanoplatform for severe acute pancreatitis: Achieving enhanced anti-inflammatory effects through calcium homeostasis restoration and oxidative stress mitigation Materials Today Bio Severe acute pancreatitis Nanoplatform Calcium Oxidative stress Mitochondrial dysfunction |
| title | Cerium-based nanoplatform for severe acute pancreatitis: Achieving enhanced anti-inflammatory effects through calcium homeostasis restoration and oxidative stress mitigation |
| title_full | Cerium-based nanoplatform for severe acute pancreatitis: Achieving enhanced anti-inflammatory effects through calcium homeostasis restoration and oxidative stress mitigation |
| title_fullStr | Cerium-based nanoplatform for severe acute pancreatitis: Achieving enhanced anti-inflammatory effects through calcium homeostasis restoration and oxidative stress mitigation |
| title_full_unstemmed | Cerium-based nanoplatform for severe acute pancreatitis: Achieving enhanced anti-inflammatory effects through calcium homeostasis restoration and oxidative stress mitigation |
| title_short | Cerium-based nanoplatform for severe acute pancreatitis: Achieving enhanced anti-inflammatory effects through calcium homeostasis restoration and oxidative stress mitigation |
| title_sort | cerium based nanoplatform for severe acute pancreatitis achieving enhanced anti inflammatory effects through calcium homeostasis restoration and oxidative stress mitigation |
| topic | Severe acute pancreatitis Nanoplatform Calcium Oxidative stress Mitochondrial dysfunction |
| url | http://www.sciencedirect.com/science/article/pii/S259000642500047X |
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