Integrative analysis of lactylation related genes in prostate cancer: unveiling heterogeneity through single-cell RNA-seq, bulk RNA-seq and machine learning

Integrative analysis of lactylation related genes in prostate cancer: unveiling heterogeneity through single-cell RNA-seq, bulk RNA-seq and machine learning

IntroductionLactylation, a post-translational modification characterized by the attachment of lactate to protein lysine residues on proteins, plays a pivotal role in cancer progression and immune evasion. However, its implications in immunity regulation and prostate cancer prognosis remains poorly u...

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Bibliographic Details
Main Authors: Chenghao Zhou, Lifeng Ding, Huailan Wang, Gonghui Li, Lei Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
prostate cancer
lactylation
prognostic biomarker
machine learning
personalized treatment
immune microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1634985/full
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