miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1
MicroRNAs (miRNAs) have been implied to play crucial roles for epithelial-to-mesenchymal transition (EMT) of non-small-cell lung cancer cells (NSCLC cells). Here we found that the expression of miR-149, downregulated in lung cancer, was inversely correlated with invasive capability and the EMT pheno...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2013/506731 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551563222056960 |
|---|---|
| author | Yang Ke Weiyong Zhao Jie Xiong Rubo Cao |
| author_facet | Yang Ke Weiyong Zhao Jie Xiong Rubo Cao |
| author_sort | Yang Ke |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) have been implied to play crucial roles for epithelial-to-mesenchymal transition (EMT) of non-small-cell lung cancer cells (NSCLC cells). Here we found that the expression of miR-149, downregulated in lung cancer, was inversely correlated with invasive capability and the EMT phenotype of NSCLC cells. miR-149 inhibited EMT in NSCLC cells. Furthermore, we demonstrated that miR-149 directly targeted Forkhead box M1 (FOXM1), and FOXM1 was involved in the EMT induced by TGF-β1 in A549 cells. Overexpression of FOXM1 restored EMT process inhibited by miR-149. Our work suggested that miR-149 might be an EMT suppressor in NSCLC cells. |
| format | Article |
| id | doaj-art-beab5b26b22c4a96a6ad857563ecb945 |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-beab5b26b22c4a96a6ad857563ecb9452025-02-03T06:01:11ZengWileyBiochemistry Research International2090-22472090-22552013-01-01201310.1155/2013/506731506731miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1Yang Ke0Weiyong Zhao1Jie Xiong2Rubo Cao3Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Oncology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, ChinaCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaMicroRNAs (miRNAs) have been implied to play crucial roles for epithelial-to-mesenchymal transition (EMT) of non-small-cell lung cancer cells (NSCLC cells). Here we found that the expression of miR-149, downregulated in lung cancer, was inversely correlated with invasive capability and the EMT phenotype of NSCLC cells. miR-149 inhibited EMT in NSCLC cells. Furthermore, we demonstrated that miR-149 directly targeted Forkhead box M1 (FOXM1), and FOXM1 was involved in the EMT induced by TGF-β1 in A549 cells. Overexpression of FOXM1 restored EMT process inhibited by miR-149. Our work suggested that miR-149 might be an EMT suppressor in NSCLC cells.http://dx.doi.org/10.1155/2013/506731 |
| spellingShingle | Yang Ke Weiyong Zhao Jie Xiong Rubo Cao miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1 Biochemistry Research International |
| title | miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1 |
| title_full | miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1 |
| title_fullStr | miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1 |
| title_full_unstemmed | miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1 |
| title_short | miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1 |
| title_sort | mir 149 inhibits non small cell lung cancer cells emt by targeting foxm1 |
| url | http://dx.doi.org/10.1155/2013/506731 |
| work_keys_str_mv | AT yangke mir149inhibitsnonsmallcelllungcancercellsemtbytargetingfoxm1 AT weiyongzhao mir149inhibitsnonsmallcelllungcancercellsemtbytargetingfoxm1 AT jiexiong mir149inhibitsnonsmallcelllungcancercellsemtbytargetingfoxm1 AT rubocao mir149inhibitsnonsmallcelllungcancercellsemtbytargetingfoxm1 |