Fabrication of a multilayer bioabsorbable composite vascular stent utilizing oxidized starch-Fe3O4 nanoparticles and polycaprolactone nanofibers
Abstract Currently, bioabsorbable polymer stents are utilized to mitigate the risk of late stent restenosis in cardiovascular applications. In this context, we propose a novel assembly that integrates polycaprolactone (PCL) nano-fibers and oxidized starch (OS) with iron oxide nanoparticles (IONPs) t...
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Nature Portfolio
2025-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-86111-x |
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| author | Fatemeh Hataminia Reza Faridi-Majidi Seyed Mohammad Amin Hashemi Hossein Ghanbari |
| author_facet | Fatemeh Hataminia Reza Faridi-Majidi Seyed Mohammad Amin Hashemi Hossein Ghanbari |
| author_sort | Fatemeh Hataminia |
| collection | DOAJ |
| description | Abstract Currently, bioabsorbable polymer stents are utilized to mitigate the risk of late stent restenosis in cardiovascular applications. In this context, we propose a novel assembly that integrates polycaprolactone (PCL) nano-fibers and oxidized starch (OS) with iron oxide nanoparticles (IONPs) to create a rigid-swelling scaffold for cardiovascular stents. This study fabricates the nanocomposite (NC) using a combination of electrospinning and electrospray techniques. The stent body is formed by leveraging the self-adhesive (SA) properties of multiple NC sheets, resulting in a multilayer (ML) structure. To achieve the desired stent shape, we employed the CO2 laser cutting method on a specific pattern after rolling the prepared sheets in two steps: OS hydration followed by melting the polymer between layers during the cutting process. Our results show that the multilayer structure of the cardiovascular stent body demonstrates favorable in vitro mechanical properties and biocompatibility. |
| format | Article |
| id | doaj-art-be9d93bcecf44b8f85ce9c1e1e4f7471 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-be9d93bcecf44b8f85ce9c1e1e4f74712025-08-20T03:05:53ZengNature PortfolioScientific Reports2045-23222025-03-0115111510.1038/s41598-025-86111-xFabrication of a multilayer bioabsorbable composite vascular stent utilizing oxidized starch-Fe3O4 nanoparticles and polycaprolactone nanofibersFatemeh Hataminia0Reza Faridi-Majidi1Seyed Mohammad Amin Hashemi2Hossein Ghanbari3Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical SciencesDepartment of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical SciencesDepartment of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical SciencesDepartment of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical SciencesAbstract Currently, bioabsorbable polymer stents are utilized to mitigate the risk of late stent restenosis in cardiovascular applications. In this context, we propose a novel assembly that integrates polycaprolactone (PCL) nano-fibers and oxidized starch (OS) with iron oxide nanoparticles (IONPs) to create a rigid-swelling scaffold for cardiovascular stents. This study fabricates the nanocomposite (NC) using a combination of electrospinning and electrospray techniques. The stent body is formed by leveraging the self-adhesive (SA) properties of multiple NC sheets, resulting in a multilayer (ML) structure. To achieve the desired stent shape, we employed the CO2 laser cutting method on a specific pattern after rolling the prepared sheets in two steps: OS hydration followed by melting the polymer between layers during the cutting process. Our results show that the multilayer structure of the cardiovascular stent body demonstrates favorable in vitro mechanical properties and biocompatibility.https://doi.org/10.1038/s41598-025-86111-xNanocompositesThermoplastic starchLayered structuresElectrospinningLaser cutting |
| spellingShingle | Fatemeh Hataminia Reza Faridi-Majidi Seyed Mohammad Amin Hashemi Hossein Ghanbari Fabrication of a multilayer bioabsorbable composite vascular stent utilizing oxidized starch-Fe3O4 nanoparticles and polycaprolactone nanofibers Scientific Reports Nanocomposites Thermoplastic starch Layered structures Electrospinning Laser cutting |
| title | Fabrication of a multilayer bioabsorbable composite vascular stent utilizing oxidized starch-Fe3O4 nanoparticles and polycaprolactone nanofibers |
| title_full | Fabrication of a multilayer bioabsorbable composite vascular stent utilizing oxidized starch-Fe3O4 nanoparticles and polycaprolactone nanofibers |
| title_fullStr | Fabrication of a multilayer bioabsorbable composite vascular stent utilizing oxidized starch-Fe3O4 nanoparticles and polycaprolactone nanofibers |
| title_full_unstemmed | Fabrication of a multilayer bioabsorbable composite vascular stent utilizing oxidized starch-Fe3O4 nanoparticles and polycaprolactone nanofibers |
| title_short | Fabrication of a multilayer bioabsorbable composite vascular stent utilizing oxidized starch-Fe3O4 nanoparticles and polycaprolactone nanofibers |
| title_sort | fabrication of a multilayer bioabsorbable composite vascular stent utilizing oxidized starch fe3o4 nanoparticles and polycaprolactone nanofibers |
| topic | Nanocomposites Thermoplastic starch Layered structures Electrospinning Laser cutting |
| url | https://doi.org/10.1038/s41598-025-86111-x |
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