Circulating T-cell receptor repertoire for cancer early detection

Circulating T-cell receptor repertoire for cancer early detection

Abstract Liquid biopsy is a promising non-invasive technology that is capable of diagnosing cancer. However, current ctDNA-based approaches detect only a minority of early-stage disease. We set out to improve the sensitivity of liquid biopsy by harnessing tumor recognition by T cells through the seq...

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Main Authors: Yilong Li, Michelle Nahas, Dennis Stephens, Kate Froburg, Emma Hintz, Devin Champagne, Amaneet Lochab, Markus Brown, Jasper Braun, María Antonia Fortuño, María-del-Mar Ocón, Andrea Pasquier, Inés Luque-Vázquez, Hita Moudgalya, Sophie Kivlehan, Iliana Gjeci, Stephanie L. Korle, Arantza Campo, Maria Rodriguez, Christopher W. Seder, Patrick H. Lizotte, Raphael Bueno, Jeffrey A. Borgia, Luis M. Seijo, Luis M. Montuenga, Roman Yelensky
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-01036-y
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https://doi.org/10.1038/s41698-025-01036-y

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