The Fatty Acid Profile in Patients with Newly Diagnosed Diabetes: Why It Could Be Unsuspected
Context. Several studies have shown a link between proinflammatory activity and the presence or deficit of some fatty acids. Inflammation is associated with several diseases including diabetes. Objective. To characterize and compare the fatty acids profiles in children with inaugural type 1 diabetes...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2017/6424186 |
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| author | C. Castro-Correia S. Sousa S. Norberto C. Matos V. F. Domingues M. Fontoura C. Calhau |
| author_facet | C. Castro-Correia S. Sousa S. Norberto C. Matos V. F. Domingues M. Fontoura C. Calhau |
| author_sort | C. Castro-Correia |
| collection | DOAJ |
| description | Context. Several studies have shown a link between proinflammatory activity and the presence or deficit of some fatty acids. Inflammation is associated with several diseases including diabetes. Objective. To characterize and compare the fatty acids profiles in children with inaugural type 1 diabetes, diabetic children (at least 1 year after diagnosis), and healthy children. Design. Plasma fatty acids profiles in children with inaugural diabetes, children with noninaugural diabetes, and controls, all of whom were prepubescent with a BMI < 85th percentile, were evaluated. Results. Omega-3 fatty acid levels were higher in recently diagnosed subjects with diabetes than in controls. The ratio of omega-6/omega-3 fatty acids was higher in the control population. Omega-6 fatty acid levels were higher in the nonrecent diabetic subjects than in the children with recently diagnosed diabetes, and the levels were higher in the nonrecent diabetes group compared to the control group. Conclusion. Our findings showed higher levels of alpha-linolenic acid, EPA, and DHA, as well as mono- and polyunsaturated fatty acids, in diabetic children. These findings reinforce the importance of precocious nutritional attention and intervention in the treatment of diabetic children. |
| format | Article |
| id | doaj-art-be89d4e7c8c3457da34859a9a0f3033f |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-be89d4e7c8c3457da34859a9a0f3033f2025-02-03T07:25:05ZengWileyInternational Journal of Pediatrics1687-97401687-97592017-01-01201710.1155/2017/64241866424186The Fatty Acid Profile in Patients with Newly Diagnosed Diabetes: Why It Could Be UnsuspectedC. Castro-Correia0S. Sousa1S. Norberto2C. Matos3V. F. Domingues4M. Fontoura5C. Calhau6Unidade de Endocrinologia Pediátrica, Hospital Pediátrico Integrado, Centro Hospitalar S. João, Faculty of Medicine, University of Porto, 4200 Porto, PortugalREQUIMTE/LAQV-GRAQ, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, 4200-072 Porto, PortugalDepartment of Biochemistry, Faculty of Medicine, University of Porto, Centro de Investigação Médica, 4200-450 Porto, PortugalCenter for Research in Health Technologies and Information Systems (CINTESIS), 4200-450 Porto, PortugalREQUIMTE/LAQV-GRAQ, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, 4200-072 Porto, PortugalUnidade de Endocrinologia Pediátrica, Hospital Pediátrico Integrado, Centro Hospitalar S. João, Faculty of Medicine, University of Porto, 4200 Porto, PortugalDepartment of Biochemistry, Faculty of Medicine, University of Porto, Centro de Investigação Médica, 4200-450 Porto, PortugalContext. Several studies have shown a link between proinflammatory activity and the presence or deficit of some fatty acids. Inflammation is associated with several diseases including diabetes. Objective. To characterize and compare the fatty acids profiles in children with inaugural type 1 diabetes, diabetic children (at least 1 year after diagnosis), and healthy children. Design. Plasma fatty acids profiles in children with inaugural diabetes, children with noninaugural diabetes, and controls, all of whom were prepubescent with a BMI < 85th percentile, were evaluated. Results. Omega-3 fatty acid levels were higher in recently diagnosed subjects with diabetes than in controls. The ratio of omega-6/omega-3 fatty acids was higher in the control population. Omega-6 fatty acid levels were higher in the nonrecent diabetic subjects than in the children with recently diagnosed diabetes, and the levels were higher in the nonrecent diabetes group compared to the control group. Conclusion. Our findings showed higher levels of alpha-linolenic acid, EPA, and DHA, as well as mono- and polyunsaturated fatty acids, in diabetic children. These findings reinforce the importance of precocious nutritional attention and intervention in the treatment of diabetic children.http://dx.doi.org/10.1155/2017/6424186 |
| spellingShingle | C. Castro-Correia S. Sousa S. Norberto C. Matos V. F. Domingues M. Fontoura C. Calhau The Fatty Acid Profile in Patients with Newly Diagnosed Diabetes: Why It Could Be Unsuspected International Journal of Pediatrics |
| title | The Fatty Acid Profile in Patients with Newly Diagnosed Diabetes: Why It Could Be Unsuspected |
| title_full | The Fatty Acid Profile in Patients with Newly Diagnosed Diabetes: Why It Could Be Unsuspected |
| title_fullStr | The Fatty Acid Profile in Patients with Newly Diagnosed Diabetes: Why It Could Be Unsuspected |
| title_full_unstemmed | The Fatty Acid Profile in Patients with Newly Diagnosed Diabetes: Why It Could Be Unsuspected |
| title_short | The Fatty Acid Profile in Patients with Newly Diagnosed Diabetes: Why It Could Be Unsuspected |
| title_sort | fatty acid profile in patients with newly diagnosed diabetes why it could be unsuspected |
| url | http://dx.doi.org/10.1155/2017/6424186 |
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