Liver Transplant From a Deceased Donor With Cystinosis: A Case Report
ABSTRACT Many inherited metabolic disorders (IMD) are associated with end‐organ damage necessitating organ transplantation. Although utilization of deceased donors with history of IMD warrants caution, there may be circumstances under which such donors could be considered as suitable organ donor can...
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Wiley
2025-01-01
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| Series: | JIMD Reports |
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| Online Access: | https://doi.org/10.1002/jmd2.12467 |
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| author | Raeda Taj Kim Ng Sanmati R. Cuddapah Elizabeth B. Rand Melissa Bleicher Sandra Amaral Maarouf A. Hoteit Rajendar K. Reddy Eyob Feyssa Emma E. Furth Kim M. Olthoff Samir Abu‐Gazala Matthew H. Levine Frederick Vyas Peter L. Abt |
| author_facet | Raeda Taj Kim Ng Sanmati R. Cuddapah Elizabeth B. Rand Melissa Bleicher Sandra Amaral Maarouf A. Hoteit Rajendar K. Reddy Eyob Feyssa Emma E. Furth Kim M. Olthoff Samir Abu‐Gazala Matthew H. Levine Frederick Vyas Peter L. Abt |
| author_sort | Raeda Taj |
| collection | DOAJ |
| description | ABSTRACT Many inherited metabolic disorders (IMD) are associated with end‐organ damage necessitating organ transplantation. Although utilization of deceased donors with history of IMD warrants caution, there may be circumstances under which such donors could be considered as suitable organ donor candidates. We present the first known report of liver transplantation from a deceased donor with cystinosis. The donor was a 20‐year‐old male with infantile cystinosis who had previously undergone two deceased donor kidney transplants. Unfortunately, he incurred cranial trauma, and after careful consideration of the metabolic consequences, his liver was deemed suitable for transplantation. The liver was successfully transplanted into a 65‐year‐old female recipient with hepatitis C (HCV) cirrhosis. The recipient is currently 12 months post‐transplant and experiencing good graft function without evidence of cystine crystals on liver biopsy. This case highlights that liver transplantation from donors with rare IMD can result in favorable outcomes. However, it is crucial to approach the use of such livers with caution. These transplants should be considered after a thorough assessment, ensuring that a comprehensive decision‐making process is in place to mitigate potential risks. |
| format | Article |
| id | doaj-art-be754681cb504498a02157428cece042 |
| institution | Kabale University |
| issn | 2192-8312 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | JIMD Reports |
| spelling | doaj-art-be754681cb504498a02157428cece0422025-01-28T07:38:32ZengWileyJIMD Reports2192-83122025-01-01661n/an/a10.1002/jmd2.12467Liver Transplant From a Deceased Donor With Cystinosis: A Case ReportRaeda Taj0Kim Ng1Sanmati R. Cuddapah2Elizabeth B. Rand3Melissa Bleicher4Sandra Amaral5Maarouf A. Hoteit6Rajendar K. Reddy7Eyob Feyssa8Emma E. Furth9Kim M. Olthoff10Samir Abu‐Gazala11Matthew H. Levine12Frederick Vyas13Peter L. Abt14Department of Surgery, Transplant Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania USADivision of Human Genetics Children's Hospital of Philadelphia Philadelphia Pennsylvania USADivision of Human Genetics Children's Hospital of Philadelphia Philadelphia Pennsylvania USADepartment of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition Children's Hospital of Philadelphia Philadelphia Pennsylvania USADivision of Nephrology, Department of Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania USADivision of Nephrology, The Children's Hospital of Philadelphia, Department of Pediatrics and Department of Biostatistics, Epidemiology and Informatics Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USADivision of Gastroenterology and Hepatology Hospital of the University of Pennsylvania Philadelphia Pennsylvania USADivision of Gastroenterology and Hepatology Hospital of the University of Pennsylvania Philadelphia Pennsylvania USADivision of Gastroenterology and Hepatology Hospital of the University of Pennsylvania Philadelphia Pennsylvania USADepartment of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania USADepartment of Surgery, Transplant Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania USADepartment of Surgery, Transplant Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania USADepartment of Surgery, Transplant Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania USADepartment of Surgery, Transplant Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania USADepartment of Surgery, Transplant Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania USAABSTRACT Many inherited metabolic disorders (IMD) are associated with end‐organ damage necessitating organ transplantation. Although utilization of deceased donors with history of IMD warrants caution, there may be circumstances under which such donors could be considered as suitable organ donor candidates. We present the first known report of liver transplantation from a deceased donor with cystinosis. The donor was a 20‐year‐old male with infantile cystinosis who had previously undergone two deceased donor kidney transplants. Unfortunately, he incurred cranial trauma, and after careful consideration of the metabolic consequences, his liver was deemed suitable for transplantation. The liver was successfully transplanted into a 65‐year‐old female recipient with hepatitis C (HCV) cirrhosis. The recipient is currently 12 months post‐transplant and experiencing good graft function without evidence of cystine crystals on liver biopsy. This case highlights that liver transplantation from donors with rare IMD can result in favorable outcomes. However, it is crucial to approach the use of such livers with caution. These transplants should be considered after a thorough assessment, ensuring that a comprehensive decision‐making process is in place to mitigate potential risks.https://doi.org/10.1002/jmd2.12467cystinosisinherited metabolic disordersliver transplant |
| spellingShingle | Raeda Taj Kim Ng Sanmati R. Cuddapah Elizabeth B. Rand Melissa Bleicher Sandra Amaral Maarouf A. Hoteit Rajendar K. Reddy Eyob Feyssa Emma E. Furth Kim M. Olthoff Samir Abu‐Gazala Matthew H. Levine Frederick Vyas Peter L. Abt Liver Transplant From a Deceased Donor With Cystinosis: A Case Report JIMD Reports cystinosis inherited metabolic disorders liver transplant |
| title | Liver Transplant From a Deceased Donor With Cystinosis: A Case Report |
| title_full | Liver Transplant From a Deceased Donor With Cystinosis: A Case Report |
| title_fullStr | Liver Transplant From a Deceased Donor With Cystinosis: A Case Report |
| title_full_unstemmed | Liver Transplant From a Deceased Donor With Cystinosis: A Case Report |
| title_short | Liver Transplant From a Deceased Donor With Cystinosis: A Case Report |
| title_sort | liver transplant from a deceased donor with cystinosis a case report |
| topic | cystinosis inherited metabolic disorders liver transplant |
| url | https://doi.org/10.1002/jmd2.12467 |
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