Exosomes and immune modulation: implications for neuroblastoma immunotherapy

Exosomes and immune modulation: implications for neuroblastoma immunotherapy

Exosomes are nano-sized extracellular vesicles involved in cell homeostasis. Tumor-derived exosomes (TDEs) promote tumor progression by creating an immunosuppressive tumor microenvironment (TME), inhibiting T and NK cell activity, preventing dendritic cell maturation, and expanding immunosuppressive...

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Bibliographic Details
Main Authors: Martina Morini, Chiara Vitale, Martina Ardito, Alessandra Dondero, Katia Cortese, Cristina Bottino, Roberta Castriconi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
exosomes
immunotherapy
tumor microenvironment
neuroblastoma
NK cells
cancer stem cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1600062/full
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