Nonmotor Symptoms in Patients with PARK2 Mutations
Decreased 123I-meta-iodobenzylguanidine (MIBG) uptake in MIBG myocardial scintigraphy, olfactory dysfunction, and rapid eye movement (REM) sleep behavior disorder (RBD) are considered useful early indicators of Parkinson disease. We investigated whether patients with PARK2 mutations exhibited myocar...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.4061/2011/473640 |
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| author | Asako Yoritaka Yumi Shimo Yasushi Shimo Yuichi Inoue Hiroyo Yoshino Nobutaka Hattori |
| author_facet | Asako Yoritaka Yumi Shimo Yasushi Shimo Yuichi Inoue Hiroyo Yoshino Nobutaka Hattori |
| author_sort | Asako Yoritaka |
| collection | DOAJ |
| description | Decreased 123I-meta-iodobenzylguanidine (MIBG) uptake in MIBG myocardial scintigraphy, olfactory dysfunction, and rapid eye movement (REM) sleep behavior disorder (RBD) are considered useful early indicators of Parkinson disease. We investigated whether patients with PARK2 mutations exhibited myocardial sympathetic abnormalities using MIBG scintigraphy, olfactory dysfunction using the Sniffin’ Sticks olfactory test, and RBD using polysomnography. None of the examined patients had RBD, and all except 1 patient exhibited an increase in the olfactory threshold. Moreover, one of the oldest patients exhibited impairment in identification and discrimination. Of 12 patients with PARK2 mutations, 4 patients, who were older than patients without abnormal uptake, exhibited decreased MIBG uptake. The results obtained in this study suggest that some patients with PARK2 mutations have increased thresholds of olfactory function and myocardial sympathetic dysfunction as nonmotor symptoms. |
| format | Article |
| id | doaj-art-be6325f2bd0949b6a9231c7e3053cd88 |
| institution | Kabale University |
| issn | 2042-0080 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-be6325f2bd0949b6a9231c7e3053cd882025-02-03T00:59:27ZengWileyParkinson's Disease2042-00802011-01-01201110.4061/2011/473640473640Nonmotor Symptoms in Patients with PARK2 MutationsAsako Yoritaka0Yumi Shimo1Yasushi Shimo2Yuichi Inoue3Hiroyo Yoshino4Nobutaka Hattori5Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanJapan Somnology Center, Neuropsychiatric Research Institute, 1-24-10 Yoyogi, Shibuya-ku, Tokyo 151-0053, JapanDepartment of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDecreased 123I-meta-iodobenzylguanidine (MIBG) uptake in MIBG myocardial scintigraphy, olfactory dysfunction, and rapid eye movement (REM) sleep behavior disorder (RBD) are considered useful early indicators of Parkinson disease. We investigated whether patients with PARK2 mutations exhibited myocardial sympathetic abnormalities using MIBG scintigraphy, olfactory dysfunction using the Sniffin’ Sticks olfactory test, and RBD using polysomnography. None of the examined patients had RBD, and all except 1 patient exhibited an increase in the olfactory threshold. Moreover, one of the oldest patients exhibited impairment in identification and discrimination. Of 12 patients with PARK2 mutations, 4 patients, who were older than patients without abnormal uptake, exhibited decreased MIBG uptake. The results obtained in this study suggest that some patients with PARK2 mutations have increased thresholds of olfactory function and myocardial sympathetic dysfunction as nonmotor symptoms.http://dx.doi.org/10.4061/2011/473640 |
| spellingShingle | Asako Yoritaka Yumi Shimo Yasushi Shimo Yuichi Inoue Hiroyo Yoshino Nobutaka Hattori Nonmotor Symptoms in Patients with PARK2 Mutations Parkinson's Disease |
| title | Nonmotor Symptoms in Patients with PARK2 Mutations |
| title_full | Nonmotor Symptoms in Patients with PARK2 Mutations |
| title_fullStr | Nonmotor Symptoms in Patients with PARK2 Mutations |
| title_full_unstemmed | Nonmotor Symptoms in Patients with PARK2 Mutations |
| title_short | Nonmotor Symptoms in Patients with PARK2 Mutations |
| title_sort | nonmotor symptoms in patients with park2 mutations |
| url | http://dx.doi.org/10.4061/2011/473640 |
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