Tannic acid-loaded inorganic-organic coating on magnesium bone nails for enhanced antibacterial, anti-inflammatory and corrosion resistance
In fracture fixation surgery, an ideal bone nail implant should initially provide stable support for the fractured bone and subsequently promote callus formation and bone remodeling. Magnesium alloy is a promising material due to its high mechanical strength, strong osteoinductive ability, superior...
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Elsevier
2025-01-01
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| Series: | Journal of Materials Research and Technology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2238785424030709 |
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| author | Sirui Xu Chuanyao Dong Xiaolin Yu Tianshu Lv Dapeng Zeng Ruiyan Li Xingfu Bao Kan Zhang |
| author_facet | Sirui Xu Chuanyao Dong Xiaolin Yu Tianshu Lv Dapeng Zeng Ruiyan Li Xingfu Bao Kan Zhang |
| author_sort | Sirui Xu |
| collection | DOAJ |
| description | In fracture fixation surgery, an ideal bone nail implant should initially provide stable support for the fractured bone and subsequently promote callus formation and bone remodeling. Magnesium alloy is a promising material due to its high mechanical strength, strong osteoinductive ability, superior biodegradability, and density comparable to that of natural bone. However, its excessive corrosion rate and susceptibility to bacterial infection have significantly limited its use as an intramedullary nailing material. Here, we develop a dual-layer structural coating with the micro-arc oxidation layer and tannic acid-doped chitosan layer (TA-CS/MAO) on the magnesium alloy from bottom to up. The micro-arc oxidation layer improves adhesion to the magnesium alloy, while the addition of chitosan increases coating density through interlaced pores. This composite coating significantly improves the corrosion resistance of magnesium alloy, positively shifting its corrosion potential by 1096 mV, current density to 4.93 × 10⁻⁹ A/cm2, and increasing impedance to 10⁶ Ω·cm2, thereby ensuring prolonged structural stability and support for bone healing. Moreover, the incorporation of tannic acid and chitosan imparts strong antibacterial and anti-inflammatory properties, achieving over 90% bacterial inhibition in vitro, mitigating infection risks, and enhancing osteogenic activity. In vivo experiments confirmed that the magnesium implant with the TA-CS/MAO coating exhibits superior antibacterial, anti-inflammatory, and osteoinductive properties. This inorganic-organic composite coating presents a promising strategy for enhancing the corrosion resistance and biomedical properties of magnesium alloys, with potential applications in other implant materials, such as titanium alloys. |
| format | Article |
| id | doaj-art-be5f8a7ffd2b452aac0a03b010e23f30 |
| institution | Kabale University |
| issn | 2238-7854 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Materials Research and Technology |
| spelling | doaj-art-be5f8a7ffd2b452aac0a03b010e23f302025-01-19T06:26:02ZengElsevierJournal of Materials Research and Technology2238-78542025-01-013428852898Tannic acid-loaded inorganic-organic coating on magnesium bone nails for enhanced antibacterial, anti-inflammatory and corrosion resistanceSirui Xu0Chuanyao Dong1Xiaolin Yu2Tianshu Lv3Dapeng Zeng4Ruiyan Li5Xingfu Bao6Kan Zhang7Department of Materials Science and Key Laboratory of Automobile Materials, MOE, State Key Laboratory of Superhard Materials, Jilin University, Changchun, 130012, ChinaDepartment of Materials Science and Key Laboratory of Automobile Materials, MOE, State Key Laboratory of Superhard Materials, Jilin University, Changchun, 130012, ChinaDepartment of Orthodontics, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, 130021, ChinaDepartment of Materials Science and Key Laboratory of Automobile Materials, MOE, State Key Laboratory of Superhard Materials, Jilin University, Changchun, 130012, ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, Jilin University, Changchun, ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, Jilin University, Changchun, ChinaDepartment of Orthodontics, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, 130021, China; Corresponding author.Department of Materials Science and Key Laboratory of Automobile Materials, MOE, State Key Laboratory of Superhard Materials, Jilin University, Changchun, 130012, China; International Center of Future Science, Jilin University, Changchun, China; Corresponding author. Department of Materials Science and Key Laboratory of Automobile Materials, MOE, State Key Laboratory of Superhard Materials, Jilin University, Changchun, 130012, China.In fracture fixation surgery, an ideal bone nail implant should initially provide stable support for the fractured bone and subsequently promote callus formation and bone remodeling. Magnesium alloy is a promising material due to its high mechanical strength, strong osteoinductive ability, superior biodegradability, and density comparable to that of natural bone. However, its excessive corrosion rate and susceptibility to bacterial infection have significantly limited its use as an intramedullary nailing material. Here, we develop a dual-layer structural coating with the micro-arc oxidation layer and tannic acid-doped chitosan layer (TA-CS/MAO) on the magnesium alloy from bottom to up. The micro-arc oxidation layer improves adhesion to the magnesium alloy, while the addition of chitosan increases coating density through interlaced pores. This composite coating significantly improves the corrosion resistance of magnesium alloy, positively shifting its corrosion potential by 1096 mV, current density to 4.93 × 10⁻⁹ A/cm2, and increasing impedance to 10⁶ Ω·cm2, thereby ensuring prolonged structural stability and support for bone healing. Moreover, the incorporation of tannic acid and chitosan imparts strong antibacterial and anti-inflammatory properties, achieving over 90% bacterial inhibition in vitro, mitigating infection risks, and enhancing osteogenic activity. In vivo experiments confirmed that the magnesium implant with the TA-CS/MAO coating exhibits superior antibacterial, anti-inflammatory, and osteoinductive properties. This inorganic-organic composite coating presents a promising strategy for enhancing the corrosion resistance and biomedical properties of magnesium alloys, with potential applications in other implant materials, such as titanium alloys.http://www.sciencedirect.com/science/article/pii/S2238785424030709MagnesiumBiodegradable implantsAntibacterialAnti-inflammatoryOsteogenic |
| spellingShingle | Sirui Xu Chuanyao Dong Xiaolin Yu Tianshu Lv Dapeng Zeng Ruiyan Li Xingfu Bao Kan Zhang Tannic acid-loaded inorganic-organic coating on magnesium bone nails for enhanced antibacterial, anti-inflammatory and corrosion resistance Journal of Materials Research and Technology Magnesium Biodegradable implants Antibacterial Anti-inflammatory Osteogenic |
| title | Tannic acid-loaded inorganic-organic coating on magnesium bone nails for enhanced antibacterial, anti-inflammatory and corrosion resistance |
| title_full | Tannic acid-loaded inorganic-organic coating on magnesium bone nails for enhanced antibacterial, anti-inflammatory and corrosion resistance |
| title_fullStr | Tannic acid-loaded inorganic-organic coating on magnesium bone nails for enhanced antibacterial, anti-inflammatory and corrosion resistance |
| title_full_unstemmed | Tannic acid-loaded inorganic-organic coating on magnesium bone nails for enhanced antibacterial, anti-inflammatory and corrosion resistance |
| title_short | Tannic acid-loaded inorganic-organic coating on magnesium bone nails for enhanced antibacterial, anti-inflammatory and corrosion resistance |
| title_sort | tannic acid loaded inorganic organic coating on magnesium bone nails for enhanced antibacterial anti inflammatory and corrosion resistance |
| topic | Magnesium Biodegradable implants Antibacterial Anti-inflammatory Osteogenic |
| url | http://www.sciencedirect.com/science/article/pii/S2238785424030709 |
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