Influence of Local Tumor Factors and Radiotherapy Dose on Prognosis of Clinical Stage T1-4N0M0 Esophageal Squamous Cell Carcinoma
ObjectiveTo investigate the effect of different radiotherapy doses on the prognosis of patients with stage cT1-4N0M0 esophageal squamous cell carcinoma (ESCC) who received radical radio (chemo)therapy categorized into subgroups with different tumor local factors. MethodsA retrospective analysis was...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Magazine House of Cancer Research on Prevention and Treatment
2025-03-01
|
| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0721 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850066728060452864 |
|---|---|
| author | Yan KONG Qian DONG Shuguang LI Jinrui XU Xiaohan ZHAO Wenzhao DENG Wenbin SHEN |
| author_facet | Yan KONG Qian DONG Shuguang LI Jinrui XU Xiaohan ZHAO Wenzhao DENG Wenbin SHEN |
| author_sort | Yan KONG |
| collection | DOAJ |
| description | ObjectiveTo investigate the effect of different radiotherapy doses on the prognosis of patients with stage cT1-4N0M0 esophageal squamous cell carcinoma (ESCC) who received radical radio (chemo)therapy categorized into subgroups with different tumor local factors. MethodsA retrospective analysis was conducted on 256 patients with clinically nonmetastatic esophageal squamous cell carcinoma. The optimal cutoff for tumor local factors was determined. The relationship between latest treatment efficacy and tumor local factors was analyzed, and independent indicators affecting patient overall survival (OS) were examined using multivariate analysis. The subgroup analysis was performed to determine the correlation between selected factors and radiation therapy doses. ResultsThe shorter the X-ray length of esophageal tumor lesion and the smaller the lesion canal wall thickness and gross tumor volume (GTV), the better the latest treatment efficacy of the patients (χ2=9.066, 10.310, 15.661, respectively, P=0.011, 0.006, P<0.001). Multivariate analysis results showed that GTV(P<0.001), radiation dose(P=0.038), and latest treatment efficacy(P<0.001) were independent predictors of the patients’ OS, and the latter two were also independent predictors of the patients’ progression-free survival (PFS) (P=0.033, <0.001). Subgroup analysis further showed that high doses of radiotherapy (over 60 Gy) resulted in good OS (χ2=5.040, 4.588, 5.400, P=0.025, 0.032, 0.020) and PFS (χ2=6.089, 4.353, 6.459, P=0.014, 0.037, 0.011) in the subgroup with maximum wall thickness below 3.7 cm, with esophageal lesions with GTV below 37.34 cm3, or not receiving simultaneous chemotherapy. ConclusionLocal tumor factors are important prognostic factors of ESCC patients treated with radical radio(chemo)therapy. Patients with thin lesion walls and small tumor volumes may greatly benefit from high doses of radiation (over 60 Gy). |
| format | Article |
| id | doaj-art-be3bffda5bd0402aa380259e94de34b1 |
| institution | DOAJ |
| issn | 1000-8578 |
| language | zho |
| publishDate | 2025-03-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj-art-be3bffda5bd0402aa380259e94de34b12025-08-20T02:48:39ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782025-03-0152322523210.3971/j.issn.1000-8578.2025.24.072120240721Influence of Local Tumor Factors and Radiotherapy Dose on Prognosis of Clinical Stage T1-4N0M0 Esophageal Squamous Cell CarcinomaYan KONG0Qian DONG1Shuguang LI2Jinrui XU3Xiaohan ZHAO4Wenzhao DENG5Wenbin SHEN6Department of Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, ChinaDepartment of Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, ChinaDepartment of Radiotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, ChinaDepartment of Radiotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, ChinaDepartment of Radiotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, ChinaDepartment of Radiotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, ChinaDepartment of Radiotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, ChinaObjectiveTo investigate the effect of different radiotherapy doses on the prognosis of patients with stage cT1-4N0M0 esophageal squamous cell carcinoma (ESCC) who received radical radio (chemo)therapy categorized into subgroups with different tumor local factors. MethodsA retrospective analysis was conducted on 256 patients with clinically nonmetastatic esophageal squamous cell carcinoma. The optimal cutoff for tumor local factors was determined. The relationship between latest treatment efficacy and tumor local factors was analyzed, and independent indicators affecting patient overall survival (OS) were examined using multivariate analysis. The subgroup analysis was performed to determine the correlation between selected factors and radiation therapy doses. ResultsThe shorter the X-ray length of esophageal tumor lesion and the smaller the lesion canal wall thickness and gross tumor volume (GTV), the better the latest treatment efficacy of the patients (χ2=9.066, 10.310, 15.661, respectively, P=0.011, 0.006, P<0.001). Multivariate analysis results showed that GTV(P<0.001), radiation dose(P=0.038), and latest treatment efficacy(P<0.001) were independent predictors of the patients’ OS, and the latter two were also independent predictors of the patients’ progression-free survival (PFS) (P=0.033, <0.001). Subgroup analysis further showed that high doses of radiotherapy (over 60 Gy) resulted in good OS (χ2=5.040, 4.588, 5.400, P=0.025, 0.032, 0.020) and PFS (χ2=6.089, 4.353, 6.459, P=0.014, 0.037, 0.011) in the subgroup with maximum wall thickness below 3.7 cm, with esophageal lesions with GTV below 37.34 cm3, or not receiving simultaneous chemotherapy. ConclusionLocal tumor factors are important prognostic factors of ESCC patients treated with radical radio(chemo)therapy. Patients with thin lesion walls and small tumor volumes may greatly benefit from high doses of radiation (over 60 Gy).http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0721esophageal squamous cell carcinomano clinical metastasistumor local factorsradiation dosesubgroupprognosis |
| spellingShingle | Yan KONG Qian DONG Shuguang LI Jinrui XU Xiaohan ZHAO Wenzhao DENG Wenbin SHEN Influence of Local Tumor Factors and Radiotherapy Dose on Prognosis of Clinical Stage T1-4N0M0 Esophageal Squamous Cell Carcinoma Zhongliu Fangzhi Yanjiu esophageal squamous cell carcinoma no clinical metastasis tumor local factors radiation dose subgroup prognosis |
| title | Influence of Local Tumor Factors and Radiotherapy Dose on Prognosis of Clinical Stage T1-4N0M0 Esophageal Squamous Cell Carcinoma |
| title_full | Influence of Local Tumor Factors and Radiotherapy Dose on Prognosis of Clinical Stage T1-4N0M0 Esophageal Squamous Cell Carcinoma |
| title_fullStr | Influence of Local Tumor Factors and Radiotherapy Dose on Prognosis of Clinical Stage T1-4N0M0 Esophageal Squamous Cell Carcinoma |
| title_full_unstemmed | Influence of Local Tumor Factors and Radiotherapy Dose on Prognosis of Clinical Stage T1-4N0M0 Esophageal Squamous Cell Carcinoma |
| title_short | Influence of Local Tumor Factors and Radiotherapy Dose on Prognosis of Clinical Stage T1-4N0M0 Esophageal Squamous Cell Carcinoma |
| title_sort | influence of local tumor factors and radiotherapy dose on prognosis of clinical stage t1 4n0m0 esophageal squamous cell carcinoma |
| topic | esophageal squamous cell carcinoma no clinical metastasis tumor local factors radiation dose subgroup prognosis |
| url | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0721 |
| work_keys_str_mv | AT yankong influenceoflocaltumorfactorsandradiotherapydoseonprognosisofclinicalstaget14n0m0esophagealsquamouscellcarcinoma AT qiandong influenceoflocaltumorfactorsandradiotherapydoseonprognosisofclinicalstaget14n0m0esophagealsquamouscellcarcinoma AT shuguangli influenceoflocaltumorfactorsandradiotherapydoseonprognosisofclinicalstaget14n0m0esophagealsquamouscellcarcinoma AT jinruixu influenceoflocaltumorfactorsandradiotherapydoseonprognosisofclinicalstaget14n0m0esophagealsquamouscellcarcinoma AT xiaohanzhao influenceoflocaltumorfactorsandradiotherapydoseonprognosisofclinicalstaget14n0m0esophagealsquamouscellcarcinoma AT wenzhaodeng influenceoflocaltumorfactorsandradiotherapydoseonprognosisofclinicalstaget14n0m0esophagealsquamouscellcarcinoma AT wenbinshen influenceoflocaltumorfactorsandradiotherapydoseonprognosisofclinicalstaget14n0m0esophagealsquamouscellcarcinoma |