Anticancer effect of curcumin on breast cancer and stem cells
Numerous studies have shown that curcumin, a natural compound, exerts anticancer effects by inhibiting cancer cell proliferation and metastasis and by inducing cell cycle arrest and apoptosis. In particular, curcumin exhibits potent inhibitory effects on breast cancer, the most prevalent type of can...
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| Language: | English |
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Tsinghua University Press
2018-06-01
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| Series: | Food Science and Human Wellness |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453018300533 |
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| author | Hui-Tien Liu Yuan-Soon Ho |
| author_facet | Hui-Tien Liu Yuan-Soon Ho |
| author_sort | Hui-Tien Liu |
| collection | DOAJ |
| description | Numerous studies have shown that curcumin, a natural compound, exerts anticancer effects by inhibiting cancer cell proliferation and metastasis and by inducing cell cycle arrest and apoptosis. In particular, curcumin exhibits potent inhibitory effects on breast cancer, the most prevalent type of cancer among women worldwide. It has low maximal inhibitory concentration for breast cancer cell lines that express the hormone receptor ER and sensitizes cell lines to anticancer drugs. Moreover, it can induce apoptosis in cell lines independently of hormone receptor expression. In addition, curcumin inhibits the proliferation of breast cancer stem cells (BCSC), an important factor that influences cancer recurrence. The inhibition of BCSC proliferation suppresses metastasis and reattachment, ultimately limiting tumor formation. A xenograft study similarly showed that curcumin exerts tumor-suppression effects on cancer cells and cancer stem cells. Therefore, curcumin is a potential anticancer compound, and its concurrent application with other anticancer drugs appears promising. Keywords: Curcumin, Breast cancer, Breast cancer stem cell |
| format | Article |
| id | doaj-art-be353745b21f491b8d17e96b23c5c3ab |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-be353745b21f491b8d17e96b23c5c3ab2025-02-03T04:01:24ZengTsinghua University PressFood Science and Human Wellness2213-45302018-06-0172134137Anticancer effect of curcumin on breast cancer and stem cellsHui-Tien Liu0Yuan-Soon Ho1Graduate Institute of Medical Sciences, College of Mediine, Taipei Medical University, Taipei, Taiwan, ROC; Corresponding author at: Graduate Institute of Medical science, College of Medicine, Taipei Medical University, Taipei, Taiwan. No. 250 Wu-Hsing street, Taipei 110, Taiwan. Tel.: +886 2 2736 1661X3420; fax: +886 2 2739 3422.Graduate Institute of Medical Sciences, College of Mediine, Taipei Medical University, Taipei, Taiwan, ROC; Graduate Institute of Medical Sciences, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, ROCNumerous studies have shown that curcumin, a natural compound, exerts anticancer effects by inhibiting cancer cell proliferation and metastasis and by inducing cell cycle arrest and apoptosis. In particular, curcumin exhibits potent inhibitory effects on breast cancer, the most prevalent type of cancer among women worldwide. It has low maximal inhibitory concentration for breast cancer cell lines that express the hormone receptor ER and sensitizes cell lines to anticancer drugs. Moreover, it can induce apoptosis in cell lines independently of hormone receptor expression. In addition, curcumin inhibits the proliferation of breast cancer stem cells (BCSC), an important factor that influences cancer recurrence. The inhibition of BCSC proliferation suppresses metastasis and reattachment, ultimately limiting tumor formation. A xenograft study similarly showed that curcumin exerts tumor-suppression effects on cancer cells and cancer stem cells. Therefore, curcumin is a potential anticancer compound, and its concurrent application with other anticancer drugs appears promising. Keywords: Curcumin, Breast cancer, Breast cancer stem cellhttp://www.sciencedirect.com/science/article/pii/S2213453018300533 |
| spellingShingle | Hui-Tien Liu Yuan-Soon Ho Anticancer effect of curcumin on breast cancer and stem cells Food Science and Human Wellness |
| title | Anticancer effect of curcumin on breast cancer and stem cells |
| title_full | Anticancer effect of curcumin on breast cancer and stem cells |
| title_fullStr | Anticancer effect of curcumin on breast cancer and stem cells |
| title_full_unstemmed | Anticancer effect of curcumin on breast cancer and stem cells |
| title_short | Anticancer effect of curcumin on breast cancer and stem cells |
| title_sort | anticancer effect of curcumin on breast cancer and stem cells |
| url | http://www.sciencedirect.com/science/article/pii/S2213453018300533 |
| work_keys_str_mv | AT huitienliu anticancereffectofcurcuminonbreastcancerandstemcells AT yuansoonho anticancereffectofcurcuminonbreastcancerandstemcells |