Comprehensive Analysis of TSPAN32 Regulatory Networks and Their Role in Immune Cell Biology
Tetraspanin 32 (TSPAN32), a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, a critical tumor-suppressor gene region. Although the biology of TSPAN32 remains largely unexplored, accumulati...
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| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/1/107 |
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| author | Grazia Scuderi Katia Mangano Maria Cristina Petralia Maria Sofia Basile Francesco Di Raimondo Paolo Fagone Ferdinando Nicoletti |
| author_facet | Grazia Scuderi Katia Mangano Maria Cristina Petralia Maria Sofia Basile Francesco Di Raimondo Paolo Fagone Ferdinando Nicoletti |
| author_sort | Grazia Scuderi |
| collection | DOAJ |
| description | Tetraspanin 32 (TSPAN32), a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, a critical tumor-suppressor gene region. Although the biology of TSPAN32 remains largely unexplored, accumulating evidence suggests its involvement in hematopoietic functions. In this study, we performed a comprehensive analysis of the expression patterns and regulatory roles of TSPAN32. Notably, TSPAN32 is highly expressed in immune cells, particularly in natural killer (NK) cells and CD8+ T cells. The observed downregulation of TSPAN32 during immune cell activation highlights its potential role as a regulator of immune cell activation and metabolic adaptations, which are crucial for effective immune responses against pathogens and tumors. Moreover, the modulation of biological processes following TSPAN32 knockout further supports its critical role in regulating immune cell physiology and responses. These findings not only shed light on the biology of TSPAN32 but also provide the basis for exploring its diagnostic, prognostic, and therapeutic potential in autoimmune and inflammatory disorders, as well as in hematopoietic cancers. |
| format | Article |
| id | doaj-art-be2bc297790b4ccaa2513bf235040e5e |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-be2bc297790b4ccaa2513bf235040e5e2025-01-24T13:25:12ZengMDPI AGBiomolecules2218-273X2025-01-0115110710.3390/biom15010107Comprehensive Analysis of TSPAN32 Regulatory Networks and Their Role in Immune Cell BiologyGrazia Scuderi0Katia Mangano1Maria Cristina Petralia2Maria Sofia Basile3Francesco Di Raimondo4Paolo Fagone5Ferdinando Nicoletti6Division of Haematology, A.O.U. Policlinico “G. Rodolico—S. Marco”, 95123 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, 98122 Messina, ItalyFaculty of Medicine, Kore University, 94100 Enna, ItalyDivision of Haematology, A.O.U. Policlinico “G. Rodolico—S. Marco”, 95123 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, ItalyTetraspanin 32 (TSPAN32), a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, a critical tumor-suppressor gene region. Although the biology of TSPAN32 remains largely unexplored, accumulating evidence suggests its involvement in hematopoietic functions. In this study, we performed a comprehensive analysis of the expression patterns and regulatory roles of TSPAN32. Notably, TSPAN32 is highly expressed in immune cells, particularly in natural killer (NK) cells and CD8+ T cells. The observed downregulation of TSPAN32 during immune cell activation highlights its potential role as a regulator of immune cell activation and metabolic adaptations, which are crucial for effective immune responses against pathogens and tumors. Moreover, the modulation of biological processes following TSPAN32 knockout further supports its critical role in regulating immune cell physiology and responses. These findings not only shed light on the biology of TSPAN32 but also provide the basis for exploring its diagnostic, prognostic, and therapeutic potential in autoimmune and inflammatory disorders, as well as in hematopoietic cancers.https://www.mdpi.com/2218-273X/15/1/107tetraspaninsTSPAN32immunity |
| spellingShingle | Grazia Scuderi Katia Mangano Maria Cristina Petralia Maria Sofia Basile Francesco Di Raimondo Paolo Fagone Ferdinando Nicoletti Comprehensive Analysis of TSPAN32 Regulatory Networks and Their Role in Immune Cell Biology Biomolecules tetraspanins TSPAN32 immunity |
| title | Comprehensive Analysis of TSPAN32 Regulatory Networks and Their Role in Immune Cell Biology |
| title_full | Comprehensive Analysis of TSPAN32 Regulatory Networks and Their Role in Immune Cell Biology |
| title_fullStr | Comprehensive Analysis of TSPAN32 Regulatory Networks and Their Role in Immune Cell Biology |
| title_full_unstemmed | Comprehensive Analysis of TSPAN32 Regulatory Networks and Their Role in Immune Cell Biology |
| title_short | Comprehensive Analysis of TSPAN32 Regulatory Networks and Their Role in Immune Cell Biology |
| title_sort | comprehensive analysis of tspan32 regulatory networks and their role in immune cell biology |
| topic | tetraspanins TSPAN32 immunity |
| url | https://www.mdpi.com/2218-273X/15/1/107 |
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