Malvidin-3-galactoside from blueberry suppresses the growth and metastasis potential of hepatocellular carcinoma cell Huh-7 by regulating apoptosis and metastases pathways
Malvidin-3-galactoside (Mv-3-gal) is the major anthocyanin monomer in blueberry anthocyanins. The compound is well-characterized by its anti-oncogenesis function in multiple organs including liver. In the current study, the mechanism driving the anti-hepatocellular carcinoma (HCC) function of Mv-3-g...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2020-06-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453019302162 |
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| author | Jie Lin Jinlong Tian Chi Shu Zhen Cheng Yunen Liu Weisheng Wang Ruihai Liu Bin Li Yuehua Wang |
| author_facet | Jie Lin Jinlong Tian Chi Shu Zhen Cheng Yunen Liu Weisheng Wang Ruihai Liu Bin Li Yuehua Wang |
| author_sort | Jie Lin |
| collection | DOAJ |
| description | Malvidin-3-galactoside (Mv-3-gal) is the major anthocyanin monomer in blueberry anthocyanins. The compound is well-characterized by its anti-oncogenesis function in multiple organs including liver. In the current study, the mechanism driving the anti-hepatocellular carcinoma (HCC) function of Mv-3-gal was further explored by focusing on apoptosis and metastases pathways. HCC cell line Huh-7 was firstly administrated with Mv-3-gal of different concentrations and the effect of Mv-3-gal on cell proliferation, apoptosis, colony formation ability, metastasis potential as well as the activity of Akt/PTEN and MAPK pathways was assessed. The results showed that Mv-3-gal inhibited the cell proliferation and colony formation ability, induced cell cycle arrest and apoptosis in a dose-dependent manner. Regarding the metastasis potential, Mv-3-gal suppressed the migration and invasion potential of Huh-7 cells by regulating MMPs expression. Taken together, the findings highlighted the anti-HCC potent of Mv-3-gal, which was associated with the inhibition of Akt/PTEN, MAPK and MMP pathways. |
| format | Article |
| id | doaj-art-be26b3d93742451284128a67f053286f |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-be26b3d93742451284128a67f053286f2025-02-03T05:38:41ZengTsinghua University PressFood Science and Human Wellness2213-45302020-06-0192136145Malvidin-3-galactoside from blueberry suppresses the growth and metastasis potential of hepatocellular carcinoma cell Huh-7 by regulating apoptosis and metastases pathwaysJie Lin0Jinlong Tian1Chi Shu2Zhen Cheng3Yunen Liu4Weisheng Wang5Ruihai Liu6Bin Li7Yuehua Wang8National R&D Professional Center For Berry Processing, Shenyang Agricultural University, Liaoning, PR ChinaNational R&D Professional Center For Berry Processing, Shenyang Agricultural University, Liaoning, PR China; Key Laborotary of Healthy Food Nutrition and Innovative Manufacturing, Liaoning, PR ChinaNational R&D Professional Center For Berry Processing, Shenyang Agricultural University, Liaoning, PR China; Key Laborotary of Healthy Food Nutrition and Innovative Manufacturing, Liaoning, PR ChinaNational R&D Professional Center For Berry Processing, Shenyang Agricultural University, Liaoning, PR ChinaEmergency Medicine Department of General Hospital of Shenyang Military Command, Laboratory of Rescue Center of Severe Trauma PLA, Liaoning, PR ChinaShenyang Blueberry Industry co. LTD., Liaoning, PR ChinaDepartment of Food Science, Cornell University, Ithaca, NY, USANational R&D Professional Center For Berry Processing, Shenyang Agricultural University, Liaoning, PR China; Key Laborotary of Healthy Food Nutrition and Innovative Manufacturing, Liaoning, PR China; Emergency Medicine Department of General Hospital of Shenyang Military Command, Laboratory of Rescue Center of Severe Trauma PLA, Liaoning, PR China; Corresponding authors at: College of Food Science, Shenyang Agricultural University, Shenyang, Liaoning, G110866, PR China.National R&D Professional Center For Berry Processing, Shenyang Agricultural University, Liaoning, PR China; Key Laborotary of Healthy Food Nutrition and Innovative Manufacturing, Liaoning, PR China; Emergency Medicine Department of General Hospital of Shenyang Military Command, Laboratory of Rescue Center of Severe Trauma PLA, Liaoning, PR China; Corresponding authors at: College of Food Science, Shenyang Agricultural University, Shenyang, Liaoning, G110866, PR China.Malvidin-3-galactoside (Mv-3-gal) is the major anthocyanin monomer in blueberry anthocyanins. The compound is well-characterized by its anti-oncogenesis function in multiple organs including liver. In the current study, the mechanism driving the anti-hepatocellular carcinoma (HCC) function of Mv-3-gal was further explored by focusing on apoptosis and metastases pathways. HCC cell line Huh-7 was firstly administrated with Mv-3-gal of different concentrations and the effect of Mv-3-gal on cell proliferation, apoptosis, colony formation ability, metastasis potential as well as the activity of Akt/PTEN and MAPK pathways was assessed. The results showed that Mv-3-gal inhibited the cell proliferation and colony formation ability, induced cell cycle arrest and apoptosis in a dose-dependent manner. Regarding the metastasis potential, Mv-3-gal suppressed the migration and invasion potential of Huh-7 cells by regulating MMPs expression. Taken together, the findings highlighted the anti-HCC potent of Mv-3-gal, which was associated with the inhibition of Akt/PTEN, MAPK and MMP pathways.http://www.sciencedirect.com/science/article/pii/S2213453019302162Malvidin-3-galactosideHepatocellular carcinomaApoptosisMAPK signaling |
| spellingShingle | Jie Lin Jinlong Tian Chi Shu Zhen Cheng Yunen Liu Weisheng Wang Ruihai Liu Bin Li Yuehua Wang Malvidin-3-galactoside from blueberry suppresses the growth and metastasis potential of hepatocellular carcinoma cell Huh-7 by regulating apoptosis and metastases pathways Food Science and Human Wellness Malvidin-3-galactoside Hepatocellular carcinoma Apoptosis MAPK signaling |
| title | Malvidin-3-galactoside from blueberry suppresses the growth and metastasis potential of hepatocellular carcinoma cell Huh-7 by regulating apoptosis and metastases pathways |
| title_full | Malvidin-3-galactoside from blueberry suppresses the growth and metastasis potential of hepatocellular carcinoma cell Huh-7 by regulating apoptosis and metastases pathways |
| title_fullStr | Malvidin-3-galactoside from blueberry suppresses the growth and metastasis potential of hepatocellular carcinoma cell Huh-7 by regulating apoptosis and metastases pathways |
| title_full_unstemmed | Malvidin-3-galactoside from blueberry suppresses the growth and metastasis potential of hepatocellular carcinoma cell Huh-7 by regulating apoptosis and metastases pathways |
| title_short | Malvidin-3-galactoside from blueberry suppresses the growth and metastasis potential of hepatocellular carcinoma cell Huh-7 by regulating apoptosis and metastases pathways |
| title_sort | malvidin 3 galactoside from blueberry suppresses the growth and metastasis potential of hepatocellular carcinoma cell huh 7 by regulating apoptosis and metastases pathways |
| topic | Malvidin-3-galactoside Hepatocellular carcinoma Apoptosis MAPK signaling |
| url | http://www.sciencedirect.com/science/article/pii/S2213453019302162 |
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