Strategies to Enhance Mesenchymal Stem Cell-Based Therapies for Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is a multifaced disease characterized by the acute onset of hypoxemia, worsened pulmonary compliance, and noncardiogenic pulmonary edema. Despite over five decades of research, specific treatments for established ARDS are still lacking. MSC-based therapies...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/5432134 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545601350270976 |
|---|---|
| author | Jibin Han Yanmin Li Yuanyuan Li |
| author_facet | Jibin Han Yanmin Li Yuanyuan Li |
| author_sort | Jibin Han |
| collection | DOAJ |
| description | Acute respiratory distress syndrome (ARDS) is a multifaced disease characterized by the acute onset of hypoxemia, worsened pulmonary compliance, and noncardiogenic pulmonary edema. Despite over five decades of research, specific treatments for established ARDS are still lacking. MSC-based therapies have the advantage of targeting nearly all pathophysiological components of ARDS by means of a variety of secreted trophic factors, exerting anti-inflammatory, antioxidative, immunomodulatory, antiapoptotic, and proangiogenic effects, resulting in significant structural and functional recovery following ARDS in various preclinical models. However, the therapeutic efficacy of transplanted MSCs is limited by their poor engraftment and low survival rate in the injured tissues, major barriers to clinical translation. Accordingly, several strategies have been explored to improve MSC retention in the lung and enhance the innate properties of MSCs in preclinical models of ARDS. To provide a comprehensive and updated view, we summarize a large body of experimental evidence for a variety of strategies directed towards strengthening the therapeutic potential of MSCs in ARDS. |
| format | Article |
| id | doaj-art-be1240db844b4aa1988c03744113edb4 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-be1240db844b4aa1988c03744113edb42025-02-03T07:25:17ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/54321345432134Strategies to Enhance Mesenchymal Stem Cell-Based Therapies for Acute Respiratory Distress SyndromeJibin Han0Yanmin Li1Yuanyuan Li2Department of Critical Care Medicine, First Hospital of Shanxi Medical University, No. 85, Jiefangnan Road, Taiyuan, 030001 Shanxi, ChinaDepartment of Anesthesiology, First Hospital of Shanxi Medical University, No. 85, Jiefangnan Road, Taiyuan, 030001 Shanxi, ChinaDepartment of Critical Care Medicine, First Hospital of Shanxi Medical University, No. 85, Jiefangnan Road, Taiyuan, 030001 Shanxi, ChinaAcute respiratory distress syndrome (ARDS) is a multifaced disease characterized by the acute onset of hypoxemia, worsened pulmonary compliance, and noncardiogenic pulmonary edema. Despite over five decades of research, specific treatments for established ARDS are still lacking. MSC-based therapies have the advantage of targeting nearly all pathophysiological components of ARDS by means of a variety of secreted trophic factors, exerting anti-inflammatory, antioxidative, immunomodulatory, antiapoptotic, and proangiogenic effects, resulting in significant structural and functional recovery following ARDS in various preclinical models. However, the therapeutic efficacy of transplanted MSCs is limited by their poor engraftment and low survival rate in the injured tissues, major barriers to clinical translation. Accordingly, several strategies have been explored to improve MSC retention in the lung and enhance the innate properties of MSCs in preclinical models of ARDS. To provide a comprehensive and updated view, we summarize a large body of experimental evidence for a variety of strategies directed towards strengthening the therapeutic potential of MSCs in ARDS.http://dx.doi.org/10.1155/2019/5432134 |
| spellingShingle | Jibin Han Yanmin Li Yuanyuan Li Strategies to Enhance Mesenchymal Stem Cell-Based Therapies for Acute Respiratory Distress Syndrome Stem Cells International |
| title | Strategies to Enhance Mesenchymal Stem Cell-Based Therapies for Acute Respiratory Distress Syndrome |
| title_full | Strategies to Enhance Mesenchymal Stem Cell-Based Therapies for Acute Respiratory Distress Syndrome |
| title_fullStr | Strategies to Enhance Mesenchymal Stem Cell-Based Therapies for Acute Respiratory Distress Syndrome |
| title_full_unstemmed | Strategies to Enhance Mesenchymal Stem Cell-Based Therapies for Acute Respiratory Distress Syndrome |
| title_short | Strategies to Enhance Mesenchymal Stem Cell-Based Therapies for Acute Respiratory Distress Syndrome |
| title_sort | strategies to enhance mesenchymal stem cell based therapies for acute respiratory distress syndrome |
| url | http://dx.doi.org/10.1155/2019/5432134 |
| work_keys_str_mv | AT jibinhan strategiestoenhancemesenchymalstemcellbasedtherapiesforacuterespiratorydistresssyndrome AT yanminli strategiestoenhancemesenchymalstemcellbasedtherapiesforacuterespiratorydistresssyndrome AT yuanyuanli strategiestoenhancemesenchymalstemcellbasedtherapiesforacuterespiratorydistresssyndrome |