Stevens-Johnson Syndrome following Failure of Genetic Screening prior to Carbamazepine Prescription
Failure to screen susceptible individuals for human leucocyte allele B∗1502 leads to the onset of Stevens-Johnson syndrome (SJS). We report a case of a 27-year-old Malay female who was treated with carbamazepine following the diagnosis of trigeminal neuralgia without a genetic screening. She was pre...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2017/4201357 |
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| _version_ | 1832560137203613696 |
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| author | Suraya Ahmad Nasir Huann Lan Tan Hui Jan Tan Haizal Mohd Hussaini Roszalina Ramli |
| author_facet | Suraya Ahmad Nasir Huann Lan Tan Hui Jan Tan Haizal Mohd Hussaini Roszalina Ramli |
| author_sort | Suraya Ahmad Nasir |
| collection | DOAJ |
| description | Failure to screen susceptible individuals for human leucocyte allele B∗1502 leads to the onset of Stevens-Johnson syndrome (SJS). We report a case of a 27-year-old Malay female who was treated with carbamazepine following the diagnosis of trigeminal neuralgia without a genetic screening. She was prescribed 150 mg of carbamazepine initially and the dose was increased to 300 mg following the initial dose. A sudden development of skin and mucous membrane ulcers was observed and this warranted immediate hospitalization. A diagnosis of SJS was made and she was treated immediately with intravenous corticosteroids. Genetic screening prior to carbamazepine prescription is essential especially in susceptible populations. |
| format | Article |
| id | doaj-art-be078f882131484e91467da47adcaff3 |
| institution | Kabale University |
| issn | 2090-6447 2090-6455 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dentistry |
| spelling | doaj-art-be078f882131484e91467da47adcaff32025-02-03T01:28:25ZengWileyCase Reports in Dentistry2090-64472090-64552017-01-01201710.1155/2017/42013574201357Stevens-Johnson Syndrome following Failure of Genetic Screening prior to Carbamazepine PrescriptionSuraya Ahmad Nasir0Huann Lan Tan1Hui Jan Tan2Haizal Mohd Hussaini3Roszalina Ramli4Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, UKM and UKM Medical Centre, Kuala Lumpur, MalaysiaDepartment of Oral & Maxillofacial Surgery, Faculty of Dentistry, UKM and UKM Medical Centre, Kuala Lumpur, MalaysiaDepartment of Medicine, Faculty of Medicine, UKM Medical Centre, Kuala Lumpur, MalaysiaDepartment of Oral Diagnostic and Surgical Sciences, Faculty of Dentistry, University of Otago, Dunedin, New ZealandDepartment of Oral & Maxillofacial Surgery, Faculty of Dentistry, UKM and UKM Medical Centre, Kuala Lumpur, MalaysiaFailure to screen susceptible individuals for human leucocyte allele B∗1502 leads to the onset of Stevens-Johnson syndrome (SJS). We report a case of a 27-year-old Malay female who was treated with carbamazepine following the diagnosis of trigeminal neuralgia without a genetic screening. She was prescribed 150 mg of carbamazepine initially and the dose was increased to 300 mg following the initial dose. A sudden development of skin and mucous membrane ulcers was observed and this warranted immediate hospitalization. A diagnosis of SJS was made and she was treated immediately with intravenous corticosteroids. Genetic screening prior to carbamazepine prescription is essential especially in susceptible populations.http://dx.doi.org/10.1155/2017/4201357 |
| spellingShingle | Suraya Ahmad Nasir Huann Lan Tan Hui Jan Tan Haizal Mohd Hussaini Roszalina Ramli Stevens-Johnson Syndrome following Failure of Genetic Screening prior to Carbamazepine Prescription Case Reports in Dentistry |
| title | Stevens-Johnson Syndrome following Failure of Genetic Screening prior to Carbamazepine Prescription |
| title_full | Stevens-Johnson Syndrome following Failure of Genetic Screening prior to Carbamazepine Prescription |
| title_fullStr | Stevens-Johnson Syndrome following Failure of Genetic Screening prior to Carbamazepine Prescription |
| title_full_unstemmed | Stevens-Johnson Syndrome following Failure of Genetic Screening prior to Carbamazepine Prescription |
| title_short | Stevens-Johnson Syndrome following Failure of Genetic Screening prior to Carbamazepine Prescription |
| title_sort | stevens johnson syndrome following failure of genetic screening prior to carbamazepine prescription |
| url | http://dx.doi.org/10.1155/2017/4201357 |
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