Multiplex imaging reveals novel patterns of MRTFA/B activation in the breast cancer microenvironment

Multiplex imaging reveals novel patterns of MRTFA/B activation in the breast cancer microenvironment

Abstract Background Breast cancer progression and metastasis involve the action of multiple transcription factors in tumors and in the cells of the tumor microenvironment (TME) and understanding how these transcription factors are coordinated can guide novel therapeutic strategies. Myocardin-related...

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Main Authors: Stephanie M. Wilk, Kihak Lee, Caitlyn C. Castillo, Mohamed Haloul, Alexa M. Gajda, Virgilia Macias, Elizabeth L. Wiley, Zhengjia Chen, Xinyi Liu, Xiaowei Wang, Maria Sverdlov, Kent F. Hoskins, Ekrem Emrah Er
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
Myocardin related transcription factors
MRTFA
MRTFB
MAL
SRF
MKL1
Online Access:https://doi.org/10.1186/s12967-025-06559-3
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https://doi.org/10.1186/s12967-025-06559-3

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