Zinc regulates microglial polarization and inflammation through IKBα after spinal cord injury and promotes neuronal repair and motor function recovery in mice

Zinc regulates microglial polarization and inflammation through IKBα after spinal cord injury and promotes neuronal repair and motor function recovery in mice

IntroductionSpinal cord injury (SCI) leads to severe inflammation and neuronal damage, resulting in permanent loss of motor and sensory functions. Zinc ions have shown potential in modulating inflammation and cellular survival, making them a promising therapeutic approach for SCI. This study investi...

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Bibliographic Details
Main Authors: Daoyong Li, Mingyu Bai, Zhanpeng Guo, Yang Cui, Xifan Mei, He Tian, Zhaoliang Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
spinal cord injury
zinc
microglial polarization
inflammatory response
functional recovery
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1510372/full
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