A Case of Proliferative Glomerulonephritis with Monoclonal IgG Deposits That Showed Predominantly Membranous Features
In 2004, the novel category of monoclonal IgG deposition disease has been proposed and termed “proliferative glomerulonephritis with monoclonal IgG deposits” (PGNMID). This disease is characterized by membranoproliferative glomerulonephritis and staining for a single light-chain isotype and gamma he...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2017/1027376 |
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| author | Homare Shimohata Kentaro Ohgi Hiroshi Maruyama Yasunori Miyamoto Mamiko Takayashu Kouichi Hirayama Masaki Kobayashi |
| author_facet | Homare Shimohata Kentaro Ohgi Hiroshi Maruyama Yasunori Miyamoto Mamiko Takayashu Kouichi Hirayama Masaki Kobayashi |
| author_sort | Homare Shimohata |
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| description | In 2004, the novel category of monoclonal IgG deposition disease has been proposed and termed “proliferative glomerulonephritis with monoclonal IgG deposits” (PGNMID). This disease is characterized by membranoproliferative glomerulonephritis and staining for a single light-chain isotype and gamma heavy-chain subclass. A 76-year-old male who had monoclonal gammopathy was referred to our hospital because of proteinuria. The renal biopsy showed diffuse thickening of the glomerular capillary walls with focal mesangial proliferation. On immunofluorescence study, only IgG1 among the four subclasses and lambda light chains were detected mainly in the glomerular capillary walls. From these results, we diagnosed our case as PGNMID showing predominantly membranous features. Almost all pathological findings on light microscopy of PGNMID are membranoproliferative GN or endocapillary proliferative GN, while membranous GN cases are rare. Here, we present the case of PGNMID that showed predominantly membranous features on light microscopy. |
| format | Article |
| id | doaj-art-bdc6ba26fa7c4498a2916babb87d0960 |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-bdc6ba26fa7c4498a2916babb87d09602025-02-03T06:41:57ZengWileyCase Reports in Nephrology2090-66412090-665X2017-01-01201710.1155/2017/10273761027376A Case of Proliferative Glomerulonephritis with Monoclonal IgG Deposits That Showed Predominantly Membranous FeaturesHomare Shimohata0Kentaro Ohgi1Hiroshi Maruyama2Yasunori Miyamoto3Mamiko Takayashu4Kouichi Hirayama5Masaki Kobayashi6Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, JapanDepartment of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, JapanDepartment of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, JapanDepartment of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, JapanDepartment of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, JapanDepartment of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, JapanDepartment of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, JapanIn 2004, the novel category of monoclonal IgG deposition disease has been proposed and termed “proliferative glomerulonephritis with monoclonal IgG deposits” (PGNMID). This disease is characterized by membranoproliferative glomerulonephritis and staining for a single light-chain isotype and gamma heavy-chain subclass. A 76-year-old male who had monoclonal gammopathy was referred to our hospital because of proteinuria. The renal biopsy showed diffuse thickening of the glomerular capillary walls with focal mesangial proliferation. On immunofluorescence study, only IgG1 among the four subclasses and lambda light chains were detected mainly in the glomerular capillary walls. From these results, we diagnosed our case as PGNMID showing predominantly membranous features. Almost all pathological findings on light microscopy of PGNMID are membranoproliferative GN or endocapillary proliferative GN, while membranous GN cases are rare. Here, we present the case of PGNMID that showed predominantly membranous features on light microscopy.http://dx.doi.org/10.1155/2017/1027376 |
| spellingShingle | Homare Shimohata Kentaro Ohgi Hiroshi Maruyama Yasunori Miyamoto Mamiko Takayashu Kouichi Hirayama Masaki Kobayashi A Case of Proliferative Glomerulonephritis with Monoclonal IgG Deposits That Showed Predominantly Membranous Features Case Reports in Nephrology |
| title | A Case of Proliferative Glomerulonephritis with Monoclonal IgG Deposits That Showed Predominantly Membranous Features |
| title_full | A Case of Proliferative Glomerulonephritis with Monoclonal IgG Deposits That Showed Predominantly Membranous Features |
| title_fullStr | A Case of Proliferative Glomerulonephritis with Monoclonal IgG Deposits That Showed Predominantly Membranous Features |
| title_full_unstemmed | A Case of Proliferative Glomerulonephritis with Monoclonal IgG Deposits That Showed Predominantly Membranous Features |
| title_short | A Case of Proliferative Glomerulonephritis with Monoclonal IgG Deposits That Showed Predominantly Membranous Features |
| title_sort | case of proliferative glomerulonephritis with monoclonal igg deposits that showed predominantly membranous features |
| url | http://dx.doi.org/10.1155/2017/1027376 |
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