Comparative Efficacy and Safety of Different Tenecteplase Doses With Alteplase in Acute Ischemic Stroke: A Systematic Review With Pairwise and Network Meta‐Analysis to Determine the Optimal Dose

Comparative Efficacy and Safety of Different Tenecteplase Doses With Alteplase in Acute Ischemic Stroke: A Systematic Review With Pairwise and Network Meta‐Analysis to Determine the Optimal Dose

ABSTRACT Background: Tenecteplase (TNK) is a novel thrombolytic agent gaining attention as an alternative to alteplase for treating acute ischemic stroke (AIS). This meta‐analysis evaluates the safety and efficacy of various TNK doses compared to alteplase, integrating recent randomized controlled t...

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Main Authors: Muhammad Hassan Waseem, Zain ul Abideen, Muhammad Haris Khan, Muhammad Fawad Tahir, Marium Khan, Hafsa Arshad Azam Raja, Ameer Haider Cheema, Sania Aimen, Muhammad Arslan Tariq, Javed Iqbal
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Brain and Behavior
Subjects:
Alteplase
dose analysis
network meta‐analysis
pairwise
stroke
thrombolytic therapy
Online Access:https://doi.org/10.1002/brb3.70756
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