Expanding Treatment Opportunities: Reviewing the Current State of Injectable Antiretrovirals for Treatment of HIV
Abstract Antiretroviral therapy has evolved significantly over the last 20–30 years, from requiring multiple tablets multiple times per day to single-tablet regimens and most recently, in 2021, long-acting injectable antiretrovirals. These long-acting antiretrovirals have expanded the treatment opti...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2024-10-01
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| Series: | Infectious Diseases and Therapy |
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| Online Access: | https://doi.org/10.1007/s40121-024-01062-6 |
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| author | Amanda Binkley Matty Zimmerman Christina Maguire |
| author_facet | Amanda Binkley Matty Zimmerman Christina Maguire |
| author_sort | Amanda Binkley |
| collection | DOAJ |
| description | Abstract Antiretroviral therapy has evolved significantly over the last 20–30 years, from requiring multiple tablets multiple times per day to single-tablet regimens and most recently, in 2021, long-acting injectable antiretrovirals. These long-acting antiretrovirals have expanded the treatment options for individuals with HIV who may have difficulty adhering to daily oral medications, difficulty taking oral medications, and/or individuals with multidrug-resistant HIV. This article reviews the currently available long-acting injectable antiretrovirals, including cabotegravir/rilpivirine, lenacapavir, and ibalizumab. The available data supporting these agents and current place in therapy will be discussed. Data supporting the use of additional long-acting injectable agents, broadly neutralizing antibodies, currently in the pipeline will be reviewed as well. |
| format | Article |
| id | doaj-art-bdb9354031784061ba03bde45d45dc8a |
| institution | Kabale University |
| issn | 2193-8229 2193-6382 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Infectious Diseases and Therapy |
| spelling | doaj-art-bdb9354031784061ba03bde45d45dc8a2024-11-24T12:37:04ZengAdis, Springer HealthcareInfectious Diseases and Therapy2193-82292193-63822024-10-0113122475248810.1007/s40121-024-01062-6Expanding Treatment Opportunities: Reviewing the Current State of Injectable Antiretrovirals for Treatment of HIVAmanda Binkley0Matty Zimmerman1Christina Maguire2Department of Pharmacy, Penn Presbyterian Medical CenterDepartment of Pharmacy, Penn Presbyterian Medical CenterDepartment of Pharmacy, Penn Presbyterian Medical CenterAbstract Antiretroviral therapy has evolved significantly over the last 20–30 years, from requiring multiple tablets multiple times per day to single-tablet regimens and most recently, in 2021, long-acting injectable antiretrovirals. These long-acting antiretrovirals have expanded the treatment options for individuals with HIV who may have difficulty adhering to daily oral medications, difficulty taking oral medications, and/or individuals with multidrug-resistant HIV. This article reviews the currently available long-acting injectable antiretrovirals, including cabotegravir/rilpivirine, lenacapavir, and ibalizumab. The available data supporting these agents and current place in therapy will be discussed. Data supporting the use of additional long-acting injectable agents, broadly neutralizing antibodies, currently in the pipeline will be reviewed as well.https://doi.org/10.1007/s40121-024-01062-6Long-acting antiretroviralsHIVAntiretroviral therapy |
| spellingShingle | Amanda Binkley Matty Zimmerman Christina Maguire Expanding Treatment Opportunities: Reviewing the Current State of Injectable Antiretrovirals for Treatment of HIV Infectious Diseases and Therapy Long-acting antiretrovirals HIV Antiretroviral therapy |
| title | Expanding Treatment Opportunities: Reviewing the Current State of Injectable Antiretrovirals for Treatment of HIV |
| title_full | Expanding Treatment Opportunities: Reviewing the Current State of Injectable Antiretrovirals for Treatment of HIV |
| title_fullStr | Expanding Treatment Opportunities: Reviewing the Current State of Injectable Antiretrovirals for Treatment of HIV |
| title_full_unstemmed | Expanding Treatment Opportunities: Reviewing the Current State of Injectable Antiretrovirals for Treatment of HIV |
| title_short | Expanding Treatment Opportunities: Reviewing the Current State of Injectable Antiretrovirals for Treatment of HIV |
| title_sort | expanding treatment opportunities reviewing the current state of injectable antiretrovirals for treatment of hiv |
| topic | Long-acting antiretrovirals HIV Antiretroviral therapy |
| url | https://doi.org/10.1007/s40121-024-01062-6 |
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