The role of PAF and leukotrienes in bioincompatibility of cuprophane membranes in hemodialysis
Inflammatory lipid mediators, PAF and leukotrienes (LTs), are thought to have an important role in biocompatibility in hemodialysis. PAF, LTB4 and LTC4 were studied both in controls (n: 12) and in 11 children on regular hemodialysis (150 minutes) with cuprophane dialyzers. Blood samples were...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
1998-07-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/3328 |
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| author | C Kabasakal S Mir A Gousseinov A Cura N Betin I Coker |
| author_facet | C Kabasakal S Mir A Gousseinov A Cura N Betin I Coker |
| author_sort | C Kabasakal |
| collection | DOAJ |
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Inflammatory lipid mediators, PAF and leukotrienes (LTs), are thought to have an important role in biocompatibility in hemodialysis. PAF, LTB4 and LTC4 were studied both in controls (n: 12) and in 11 children on regular hemodialysis (150 minutes) with cuprophane dialyzers. Blood samples were collected initially (0'-precapillary), at first minute (1'-postcapillary) and at one hour after the hemodialysis sessions (210'-venous). Presence of LTs and high levels of PAF in 0' samples compared to levels in controls and significant increases in 1' samples suggested the alterations in PAF and LTs likely originated from the peripheral leukocyte activation. In 210' samples, PAF and LTs levels were decreased but still higher than the levels in 0' samples. This study suggested that PAF and LTB4 may be the control elements in biocompatibility in hemodialysis with cuprophane membranes, and demonstrated that the effects of activation last until the following session.
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| format | Article |
| id | doaj-art-bdae09514b894604b75ca9b7cdb418f9 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 1998-07-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-bdae09514b894604b75ca9b7cdb418f92025-08-20T02:59:42ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64211998-07-01403The role of PAF and leukotrienes in bioincompatibility of cuprophane membranes in hemodialysisC Kabasakal0S MirA GousseinovA CuraN BetinI CokerDepartment of Pediatrics, Ege University, Faculty of Medicine, Tepecik Social Security Hospital, Izmir. Inflammatory lipid mediators, PAF and leukotrienes (LTs), are thought to have an important role in biocompatibility in hemodialysis. PAF, LTB4 and LTC4 were studied both in controls (n: 12) and in 11 children on regular hemodialysis (150 minutes) with cuprophane dialyzers. Blood samples were collected initially (0'-precapillary), at first minute (1'-postcapillary) and at one hour after the hemodialysis sessions (210'-venous). Presence of LTs and high levels of PAF in 0' samples compared to levels in controls and significant increases in 1' samples suggested the alterations in PAF and LTs likely originated from the peripheral leukocyte activation. In 210' samples, PAF and LTs levels were decreased but still higher than the levels in 0' samples. This study suggested that PAF and LTB4 may be the control elements in biocompatibility in hemodialysis with cuprophane membranes, and demonstrated that the effects of activation last until the following session. https://turkjpediatr.org/article/view/3328 |
| spellingShingle | C Kabasakal S Mir A Gousseinov A Cura N Betin I Coker The role of PAF and leukotrienes in bioincompatibility of cuprophane membranes in hemodialysis The Turkish Journal of Pediatrics |
| title | The role of PAF and leukotrienes in bioincompatibility of cuprophane membranes in hemodialysis |
| title_full | The role of PAF and leukotrienes in bioincompatibility of cuprophane membranes in hemodialysis |
| title_fullStr | The role of PAF and leukotrienes in bioincompatibility of cuprophane membranes in hemodialysis |
| title_full_unstemmed | The role of PAF and leukotrienes in bioincompatibility of cuprophane membranes in hemodialysis |
| title_short | The role of PAF and leukotrienes in bioincompatibility of cuprophane membranes in hemodialysis |
| title_sort | role of paf and leukotrienes in bioincompatibility of cuprophane membranes in hemodialysis |
| url | https://turkjpediatr.org/article/view/3328 |
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