Comprehensive insights into colistin and colistin resistance: updated regulations and policies on colistin usage and alternative strategies for mitigation and prevention of colistin resistance
The increase in antimicrobial resistance (AMR) has a significant impact on healthcare, leading to longer hospital stays and higher economic costs. This is primarily caused by the over and inappropriate use of antibiotics. Microorganisms have developed various mechanisms to combat the effects of a...
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ResearchersLinks, Ltd
2024-10-01
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| Series: | Novel Research in Microbiology Journal |
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| Online Access: | https://nrmj.journals.ekb.eg/article_386429_7a923e9b8e6a1db03a7079d1e134d881.pdf |
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| author | Zine El abidine Bzazou El Ouazzani Laila Reklaoui Monsif El Madany Houda Benaicha Said Barrijal |
| author_facet | Zine El abidine Bzazou El Ouazzani Laila Reklaoui Monsif El Madany Houda Benaicha Said Barrijal |
| author_sort | Zine El abidine Bzazou El Ouazzani |
| collection | DOAJ |
| description | The increase in antimicrobial resistance (AMR) has a significant impact on healthcare,
leading to longer hospital stays and higher economic costs. This is primarily caused by the
over and inappropriate use of antibiotics. Microorganisms have developed various
mechanisms to combat the effects of antibiotics, including modifying their genetic material to
evade the drugs' harmful effects. Colistin disrupts bacterial cell membranes by interacting with
lipopolysaccharides (LPS), causing cell death. Currently, colistin is regarded as a last-resort
antibiotic for treating infections caused by Gram-negative bacteria (GNB). Overuse of colistin
in animal feed and human medicine has led to the appearance of genetic mutations and the
acquisition of mobile colistin resistance (mcr) genes associated with colistin resistance. The
rapid emergence of the plasmid colistin-resistant gene further complicates treatment strategies,
emphasizing the pressing need for improved management and development of novel
antimicrobial agents. Thus, gaining an understanding of the mechanisms behind colistin
resistance and surveying its global prevalence are crucial steps in managing the growing
menace of antimicrobial resistance and safeguarding the effectiveness of existing antibiotics.
This review aimed to provide an in-depth and up-to-date overview of the colistin antibiotic,
detailing its updated modes of action and associated side effects. Additionally, it delves into
various mechanisms of resistance to colistin, advanced susceptibility test methods used for
detecting colistin resistance, and the challenges associated with these techniques. Furthermore,
the review examines the risk factors contributing to the development of colistin resistance, highlights updated regulations and policies governing colistin usage, and puts forth innovative
strategies for addressing this resistance. |
| format | Article |
| id | doaj-art-bdad83d0d8da4cf4aa4d9a0e6407b45c |
| institution | OA Journals |
| issn | 2537-0286 2537-0294 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | ResearchersLinks, Ltd |
| record_format | Article |
| series | Novel Research in Microbiology Journal |
| spelling | doaj-art-bdad83d0d8da4cf4aa4d9a0e6407b45c2025-08-20T02:02:43ZengResearchersLinks, LtdNovel Research in Microbiology Journal2537-02862537-02942024-10-01852632265210.21608/NRMJ.2024.320212.1709Comprehensive insights into colistin and colistin resistance: updated regulations and policies on colistin usage and alternative strategies for mitigation and prevention of colistin resistanceZine El abidine Bzazou El Ouazzani0 Laila Reklaoui1Monsif El Madany2Houda Benaicha3 Said Barrijal4Laboratory of Biotechnological Valorization of Microorganisms, Genomics, and Bioinformatics, Faculty of Sciences and Techniques, Abdelmalek Essaadi University, Tangier, MoroccoLaboratory of Biotechnological Valorization of Microorganisms, Genomics, and Bioinformatics, Faculty of Sciences and Techniques, Abdelmalek Essaadi University, Tangier, MoroccoLaboratory of Food Science and Health, Department of Biology, Abdelmalek Essaadi University, PO Box 2121, 93002, Tetouan, MoroccoInstitut Supérieur des Professions Infirmières et Techniques de Santé de Tanger, Tangier, MoroccoLaboratory of Biotechnological Valorization of Microorganisms, Genomics, and Bioinformatics, Faculty of Sciences and Techniques, Abdelmalek Essaadi University, Tangier, MoroccoThe increase in antimicrobial resistance (AMR) has a significant impact on healthcare, leading to longer hospital stays and higher economic costs. This is primarily caused by the over and inappropriate use of antibiotics. Microorganisms have developed various mechanisms to combat the effects of antibiotics, including modifying their genetic material to evade the drugs' harmful effects. Colistin disrupts bacterial cell membranes by interacting with lipopolysaccharides (LPS), causing cell death. Currently, colistin is regarded as a last-resort antibiotic for treating infections caused by Gram-negative bacteria (GNB). Overuse of colistin in animal feed and human medicine has led to the appearance of genetic mutations and the acquisition of mobile colistin resistance (mcr) genes associated with colistin resistance. The rapid emergence of the plasmid colistin-resistant gene further complicates treatment strategies, emphasizing the pressing need for improved management and development of novel antimicrobial agents. Thus, gaining an understanding of the mechanisms behind colistin resistance and surveying its global prevalence are crucial steps in managing the growing menace of antimicrobial resistance and safeguarding the effectiveness of existing antibiotics. This review aimed to provide an in-depth and up-to-date overview of the colistin antibiotic, detailing its updated modes of action and associated side effects. Additionally, it delves into various mechanisms of resistance to colistin, advanced susceptibility test methods used for detecting colistin resistance, and the challenges associated with these techniques. Furthermore, the review examines the risk factors contributing to the development of colistin resistance, highlights updated regulations and policies governing colistin usage, and puts forth innovative strategies for addressing this resistance.https://nrmj.journals.ekb.eg/article_386429_7a923e9b8e6a1db03a7079d1e134d881.pdfcolisitncolistin resistancemcr genelipopolysaccharidesgram-negative bacteria |
| spellingShingle | Zine El abidine Bzazou El Ouazzani Laila Reklaoui Monsif El Madany Houda Benaicha Said Barrijal Comprehensive insights into colistin and colistin resistance: updated regulations and policies on colistin usage and alternative strategies for mitigation and prevention of colistin resistance Novel Research in Microbiology Journal colisitn colistin resistance mcr gene lipopolysaccharides gram-negative bacteria |
| title | Comprehensive insights into colistin and colistin resistance: updated regulations and policies on colistin usage and alternative strategies for mitigation and prevention of colistin resistance |
| title_full | Comprehensive insights into colistin and colistin resistance: updated regulations and policies on colistin usage and alternative strategies for mitigation and prevention of colistin resistance |
| title_fullStr | Comprehensive insights into colistin and colistin resistance: updated regulations and policies on colistin usage and alternative strategies for mitigation and prevention of colistin resistance |
| title_full_unstemmed | Comprehensive insights into colistin and colistin resistance: updated regulations and policies on colistin usage and alternative strategies for mitigation and prevention of colistin resistance |
| title_short | Comprehensive insights into colistin and colistin resistance: updated regulations and policies on colistin usage and alternative strategies for mitigation and prevention of colistin resistance |
| title_sort | comprehensive insights into colistin and colistin resistance updated regulations and policies on colistin usage and alternative strategies for mitigation and prevention of colistin resistance |
| topic | colisitn colistin resistance mcr gene lipopolysaccharides gram-negative bacteria |
| url | https://nrmj.journals.ekb.eg/article_386429_7a923e9b8e6a1db03a7079d1e134d881.pdf |
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