Combining the zebrafish embryo developmental toxicity assay (ZEDTA) with hemoglobin staining to accelerate the research of novel antimalarial drugs for pregnant women

Combining the zebrafish embryo developmental toxicity assay (ZEDTA) with hemoglobin staining to accelerate the research of novel antimalarial drugs for pregnant women

Background: Malaria during pregnancy implies a high risk for the mother and the developing child. However, the therapeutic options for pregnant women have historically been very limited, especially during the first trimester of pregnancy due to potential adverse effects on embryo-fetal development....

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Main Authors: Lucia Borrallo-Lopez, Laura Guzman, Noelia G. Romero, Anna Sampietro, Ana Mallo-Abreu, Laia Guardia-Escote, Elisabet Teixidó, Burkhard Flick, Xavier Fernàndez-Busquets, Diego Muñoz-Torrero, Marta Barenys
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Alternative methods to animal experimentation
Teratogenesis
NAMs
Paludism
Drug discovery
Toxicity testing
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320725000053
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