Effect of Acute Lung Injury (ALI) Induced by Lipopolysaccharide (LPS) on the Pulmonary Pharmacokinetics of an Antibody

Effect of Acute Lung Injury (ALI) Induced by Lipopolysaccharide (LPS) on the Pulmonary Pharmacokinetics of an Antibody

Objective: To investigate the effect of Lipopolysaccharide (LPS)-induced acute lung injury (ALI) on the pulmonary pharmacokinetics (PK) of a systemically administered antibody in mice. Method: The PK of a non-target-binding antibody was evaluated in healthy mice and mice with intratracheal instillat...

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Bibliographic Details
Main Authors: Shweta Jogi, Dhaval K. Shah
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Antibodies
Subjects:
antibody
pulmonary
lung
pharmacokinetics
ALI
LPS
Online Access:https://www.mdpi.com/2073-4468/14/2/33
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