Effect of ketamine and esketamine on RNA expression and its relevance for depression: A systematic review

Effect of ketamine and esketamine on RNA expression and its relevance for depression: A systematic review

Treatment-resistant depression (TRD) remains a challenge in psychiatry, necessitating novel therapeutic strategies beyond traditional monoaminergic antidepressants. Ketamine and its S-enantiomer esketamine have demonstrated rapid and robust antidepressant effects in TRD, probably through mechanisms...

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Bibliographic Details
Main Authors: Claudia Pisanu, Rosana Carvalho Silva, Mattia Meattini, Massimo Gennarelli, Bernhard T. Baune, Alessio Squassina, Alessandra Minelli
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Pharmacological Research
Subjects:
RNA expression
Ketamine
Esketamine
Systematic review
Biomarkers
Depression
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825003196
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