Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration
Chitosan is a naturally occurring polysaccharide obtained from chitin, present in abundance in the exoskeletons of crustaceans and insects. It has aroused great interest as a biomaterial for tissue engineering on account of its biocompatibility and biodegradation and its affinity for biomolecules. A...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2017/8639898 |
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| author | José Carlos Viana Ribeiro Rodrigo Silveira Vieira Iracema Matos Melo Vilana Maria Adriano Araújo Vilma Lima |
| author_facet | José Carlos Viana Ribeiro Rodrigo Silveira Vieira Iracema Matos Melo Vilana Maria Adriano Araújo Vilma Lima |
| author_sort | José Carlos Viana Ribeiro |
| collection | DOAJ |
| description | Chitosan is a naturally occurring polysaccharide obtained from chitin, present in abundance in the exoskeletons of crustaceans and insects. It has aroused great interest as a biomaterial for tissue engineering on account of its biocompatibility and biodegradation and its affinity for biomolecules. A significant number of research groups have investigated the application of chitosan as scaffolds for tissue regeneration. However, there is a wide variability in terms of physicochemical characteristics of chitosan used in some studies and its combinations with other biomaterials, making it difficult to compare results and standardize its properties. The current systematic review of literature on the use of chitosan for tissue regeneration consisted of a study of 478 articles in the PubMed database, which resulted, after applying inclusion criteria, in the selection of 61 catalogued, critically analysed works. The results demonstrated the effectiveness of chitosan-based biomaterials in 93.4% of the studies reviewed, whether or not combined with cells and growth factors, in the regeneration of various types of tissues in animals. However, the absence of clinical studies in humans, the inadequate experimental designs, and the lack of information concerning chitosan’s characteristics limit the reproducibility and relevance of studies and the clinical applicability of chitosan. |
| format | Article |
| id | doaj-art-bd869401bcc244638b85f118fbc77e75 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-bd869401bcc244638b85f118fbc77e752025-02-03T07:25:18ZengWileyThe Scientific World Journal2356-61401537-744X2017-01-01201710.1155/2017/86398988639898Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue RegenerationJosé Carlos Viana Ribeiro0Rodrigo Silveira Vieira1Iracema Matos Melo2Vilana Maria Adriano Araújo3Vilma Lima4Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Rua Alexandre Baraúna, No. 949, Rodolfo Teófilo, 60430-160 Fortaleza, CE, BrazilDepartment of Chemical Engineering, Federal University of Ceará, Campus do Pici, Bloco 709, Pici, 60455-760 Fortaleza, CE, BrazilFaculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Rua Alexandre Baraúna, No. 949, Rodolfo Teófilo, 60430-160 Fortaleza, CE, BrazilDrug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Rua Coronel Nunes de Melo, No. 1000, Rodolfo Teófilo, 60430-275 Fortaleza, CE, BrazilDrug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Rua Coronel Nunes de Melo, No. 1000, Rodolfo Teófilo, 60430-275 Fortaleza, CE, BrazilChitosan is a naturally occurring polysaccharide obtained from chitin, present in abundance in the exoskeletons of crustaceans and insects. It has aroused great interest as a biomaterial for tissue engineering on account of its biocompatibility and biodegradation and its affinity for biomolecules. A significant number of research groups have investigated the application of chitosan as scaffolds for tissue regeneration. However, there is a wide variability in terms of physicochemical characteristics of chitosan used in some studies and its combinations with other biomaterials, making it difficult to compare results and standardize its properties. The current systematic review of literature on the use of chitosan for tissue regeneration consisted of a study of 478 articles in the PubMed database, which resulted, after applying inclusion criteria, in the selection of 61 catalogued, critically analysed works. The results demonstrated the effectiveness of chitosan-based biomaterials in 93.4% of the studies reviewed, whether or not combined with cells and growth factors, in the regeneration of various types of tissues in animals. However, the absence of clinical studies in humans, the inadequate experimental designs, and the lack of information concerning chitosan’s characteristics limit the reproducibility and relevance of studies and the clinical applicability of chitosan.http://dx.doi.org/10.1155/2017/8639898 |
| spellingShingle | José Carlos Viana Ribeiro Rodrigo Silveira Vieira Iracema Matos Melo Vilana Maria Adriano Araújo Vilma Lima Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration The Scientific World Journal |
| title | Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration |
| title_full | Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration |
| title_fullStr | Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration |
| title_full_unstemmed | Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration |
| title_short | Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration |
| title_sort | versatility of chitosan based biomaterials and their use as scaffolds for tissue regeneration |
| url | http://dx.doi.org/10.1155/2017/8639898 |
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