Alteration of fecal microbiome and metabolome by mung bean coat improves diet-induced non-alcoholic fatty liver disease in mice
Dysbiosis of gut microbiota and its derived metabolites has been linked to the occurrence and development of nonalcoholic fatty liver disease. Our previous study has demonstrated that mung bean coat (MBC) might be mainly responsible for the beneficial effects of whole mung bean on high fat diet (HFD...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2022-09-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022000611 |
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| author | Dianzhi Hou Jian Tang Meili Huan Fang Liu Sumei Zhou Qun Shen |
| author_facet | Dianzhi Hou Jian Tang Meili Huan Fang Liu Sumei Zhou Qun Shen |
| author_sort | Dianzhi Hou |
| collection | DOAJ |
| description | Dysbiosis of gut microbiota and its derived metabolites has been linked to the occurrence and development of nonalcoholic fatty liver disease. Our previous study has demonstrated that mung bean coat (MBC) might be mainly responsible for the beneficial effects of whole mung bean on high fat diet (HFD)-induced metabolic disorders. To investigate whether MBC, which is rich in dietary fiber and phytochemicals, can protect against HFD-induced hepatic steatosis in mice via targeting gut microbiota and its metabolites, we conducted this study. Results showed that MBC could effectively alleviative the obese phenotype, reduce the lipid accumulation and insulin resistance, and improve the hepatic oxidative stress and inflammatory response. Furthermore, MBC significantly prevented the HFD-induced changes in the structure and composition of gut microbiota, characterized by promoting the bloom of Akkermansia, Lachnospiraceae_NK4A136_group, and norank_f_Muribaculaceae, and along with the elevated short-chain fatty acids concentrations. Non-targeted metabolomic analysis indicated a metabolism disorder that was obviously improved by MBC via regulating sphingolipid metabolism and α-linolenic acid metabolism. These findings suggested that MBC could improve hepatic steatosis through manipulating the crosstalk between gut microbiota and its metabolites. |
| format | Article |
| id | doaj-art-bd81653ecfe5453799ab881eeb0755e9 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-bd81653ecfe5453799ab881eeb0755e92025-02-03T05:16:11ZengTsinghua University PressFood Science and Human Wellness2213-45302022-09-0111512591272Alteration of fecal microbiome and metabolome by mung bean coat improves diet-induced non-alcoholic fatty liver disease in miceDianzhi Hou0Jian Tang1Meili Huan2Fang Liu3Sumei Zhou4Qun Shen5Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China; College of Food Science and Nutritional Engineering, Key Laboratory of Plant Protein and Grain processing, China Agricultural University, Beijing 100083, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, ChinaCOFCO Nutrition and Health Research Institute, Beijing 102209, ChinaCollege of Tobacco Science, Henan Agricultural University, Zhengzhou 450002, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China; Corresponding authors.College of Food Science and Nutritional Engineering, Key Laboratory of Plant Protein and Grain processing, China Agricultural University, Beijing 100083, China; Corresponding authors.Dysbiosis of gut microbiota and its derived metabolites has been linked to the occurrence and development of nonalcoholic fatty liver disease. Our previous study has demonstrated that mung bean coat (MBC) might be mainly responsible for the beneficial effects of whole mung bean on high fat diet (HFD)-induced metabolic disorders. To investigate whether MBC, which is rich in dietary fiber and phytochemicals, can protect against HFD-induced hepatic steatosis in mice via targeting gut microbiota and its metabolites, we conducted this study. Results showed that MBC could effectively alleviative the obese phenotype, reduce the lipid accumulation and insulin resistance, and improve the hepatic oxidative stress and inflammatory response. Furthermore, MBC significantly prevented the HFD-induced changes in the structure and composition of gut microbiota, characterized by promoting the bloom of Akkermansia, Lachnospiraceae_NK4A136_group, and norank_f_Muribaculaceae, and along with the elevated short-chain fatty acids concentrations. Non-targeted metabolomic analysis indicated a metabolism disorder that was obviously improved by MBC via regulating sphingolipid metabolism and α-linolenic acid metabolism. These findings suggested that MBC could improve hepatic steatosis through manipulating the crosstalk between gut microbiota and its metabolites.http://www.sciencedirect.com/science/article/pii/S2213453022000611MBCHepatic steatosisGut microbiotaShort-chain fatty acidsMetabolites |
| spellingShingle | Dianzhi Hou Jian Tang Meili Huan Fang Liu Sumei Zhou Qun Shen Alteration of fecal microbiome and metabolome by mung bean coat improves diet-induced non-alcoholic fatty liver disease in mice Food Science and Human Wellness MBC Hepatic steatosis Gut microbiota Short-chain fatty acids Metabolites |
| title | Alteration of fecal microbiome and metabolome by mung bean coat improves diet-induced non-alcoholic fatty liver disease in mice |
| title_full | Alteration of fecal microbiome and metabolome by mung bean coat improves diet-induced non-alcoholic fatty liver disease in mice |
| title_fullStr | Alteration of fecal microbiome and metabolome by mung bean coat improves diet-induced non-alcoholic fatty liver disease in mice |
| title_full_unstemmed | Alteration of fecal microbiome and metabolome by mung bean coat improves diet-induced non-alcoholic fatty liver disease in mice |
| title_short | Alteration of fecal microbiome and metabolome by mung bean coat improves diet-induced non-alcoholic fatty liver disease in mice |
| title_sort | alteration of fecal microbiome and metabolome by mung bean coat improves diet induced non alcoholic fatty liver disease in mice |
| topic | MBC Hepatic steatosis Gut microbiota Short-chain fatty acids Metabolites |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022000611 |
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