Targeting OAS3 for reversing M2d infiltration and restoring anti-tumor immunity in pancreatic cancer

Targeting OAS3 for reversing M2d infiltration and restoring anti-tumor immunity in pancreatic cancer

Abstract Abundant infiltration of tumor-associated macrophages (TAMs) within the tumor stroma plays a pivotal role in inducing immune escape in pancreatic cancer (PC). Lactate serves as a direct regulator of macrophage polarization and functions, although the precise regulation mechanism remains ina...

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Bibliographic Details
Main Authors: Shaopeng Zhang, Ximo Xu, Kundong Zhang, Changzheng Lei, Yitian Xu, Pengshan Zhang, Yuan Zhang, Haitao Gu, Chen Huang, Zhengjun Qiu
Format: Article
Language:English
Published: Springer 2024-12-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Pancreatic cancer
M2d
OAS3
Lactate
METTL3
Online Access:https://doi.org/10.1007/s00262-024-03898-w
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