Mixed Phenotype Acute Leukemia Presenting as Leukemia Cutis
Leukemia cutis (LC) is defined as infiltration of the skin by leukemic cells resulting in clinically recognizable cutaneous lesions. It is common in congenital leukemia and acute myeloid leukemia. However, LC has rarely been reported with mixed phenotypic acute leukemia (MPAL). We report the case of...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/1298375 |
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| author | Geetha Narayanan M. T. Sugeeth Lali V. Soman |
| author_facet | Geetha Narayanan M. T. Sugeeth Lali V. Soman |
| author_sort | Geetha Narayanan |
| collection | DOAJ |
| description | Leukemia cutis (LC) is defined as infiltration of the skin by leukemic cells resulting in clinically recognizable cutaneous lesions. It is common in congenital leukemia and acute myeloid leukemia. However, LC has rarely been reported with mixed phenotypic acute leukemia (MPAL). We report the case of a lady who presented with erythematous papular and nodular lesions all over the body. Skin biopsy showed leukemic infiltration and bone marrow aspiration showed MPAL of the T/myeloid with monocytic differentiation lineage. This is the first report of an adult patient with MPAL of the T/myeloid with monocytic differentiation type presenting with leukemia cutis. She was started on chemotherapy with Hyper-CVAD. There is complete resolution of the skin lesions and she has achieved bone marrow remission after the first cycle of chemotherapy. |
| format | Article |
| id | doaj-art-bd7d2fa3ea0e4c879629be86e348c466 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-bd7d2fa3ea0e4c879629be86e348c4662025-02-03T05:53:37ZengWileyCase Reports in Medicine1687-96271687-96352016-01-01201610.1155/2016/12983751298375Mixed Phenotype Acute Leukemia Presenting as Leukemia CutisGeetha Narayanan0M. T. Sugeeth1Lali V. Soman2Department of Medical Oncology, Regional Cancer Centre, Trivandrum 695011, IndiaDepartment of Medical Oncology, Regional Cancer Centre, Trivandrum 695011, IndiaDepartment of Medical Oncology, Regional Cancer Centre, Trivandrum 695011, IndiaLeukemia cutis (LC) is defined as infiltration of the skin by leukemic cells resulting in clinically recognizable cutaneous lesions. It is common in congenital leukemia and acute myeloid leukemia. However, LC has rarely been reported with mixed phenotypic acute leukemia (MPAL). We report the case of a lady who presented with erythematous papular and nodular lesions all over the body. Skin biopsy showed leukemic infiltration and bone marrow aspiration showed MPAL of the T/myeloid with monocytic differentiation lineage. This is the first report of an adult patient with MPAL of the T/myeloid with monocytic differentiation type presenting with leukemia cutis. She was started on chemotherapy with Hyper-CVAD. There is complete resolution of the skin lesions and she has achieved bone marrow remission after the first cycle of chemotherapy.http://dx.doi.org/10.1155/2016/1298375 |
| spellingShingle | Geetha Narayanan M. T. Sugeeth Lali V. Soman Mixed Phenotype Acute Leukemia Presenting as Leukemia Cutis Case Reports in Medicine |
| title | Mixed Phenotype Acute Leukemia Presenting as Leukemia Cutis |
| title_full | Mixed Phenotype Acute Leukemia Presenting as Leukemia Cutis |
| title_fullStr | Mixed Phenotype Acute Leukemia Presenting as Leukemia Cutis |
| title_full_unstemmed | Mixed Phenotype Acute Leukemia Presenting as Leukemia Cutis |
| title_short | Mixed Phenotype Acute Leukemia Presenting as Leukemia Cutis |
| title_sort | mixed phenotype acute leukemia presenting as leukemia cutis |
| url | http://dx.doi.org/10.1155/2016/1298375 |
| work_keys_str_mv | AT geethanarayanan mixedphenotypeacuteleukemiapresentingasleukemiacutis AT mtsugeeth mixedphenotypeacuteleukemiapresentingasleukemiacutis AT lalivsoman mixedphenotypeacuteleukemiapresentingasleukemiacutis |