Variations in the diagnostic performance of transurethral resection of bladder tumor with photodynamic diagnosis according to surgical experience: A retrospective, single-center study
Background: To investigate variations in diagnostic performance of photodynamic diagnosis (PDD) according to surgical experience. Methods: Data were extracted from patients having pT1 or lower primary tumors that underwent PDD-assisted transurethral resection of bladder tumors (TURBT) with orally 5-...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024004654 |
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| author | Shuhei Suzuki Yoshiyuki Nagumo Kosuke Kojo Atsushi Ikeda Bunpei Isoda Akane Yamaguchi Kozaburo Tanuma Satoshi Nitta Masanobu Shiga Takashi Kawahara Shuya Kandori Akio Hoshi Hiromitsu Negoro Bryan J. Mathis Hiroyuki Nishiyama |
| author_facet | Shuhei Suzuki Yoshiyuki Nagumo Kosuke Kojo Atsushi Ikeda Bunpei Isoda Akane Yamaguchi Kozaburo Tanuma Satoshi Nitta Masanobu Shiga Takashi Kawahara Shuya Kandori Akio Hoshi Hiromitsu Negoro Bryan J. Mathis Hiroyuki Nishiyama |
| author_sort | Shuhei Suzuki |
| collection | DOAJ |
| description | Background: To investigate variations in diagnostic performance of photodynamic diagnosis (PDD) according to surgical experience. Methods: Data were extracted from patients having pT1 or lower primary tumors that underwent PDD-assisted transurethral resection of bladder tumors (TURBT) with orally 5-amibolevulinic acid at our institute. Surgical experience was categorized by urological experience (first-year and second-year) and PDD experience (<10, 10–19, and ≥20 cases). Sensitivity, specificity, and accuracy rates were calculated based on PDD or white light (WL) findings and pathologic diagnosis. The bladder neck, trigone, and prostatic urethra were defined as areas with a high probability of tangential effect. Results: A total of 108 patients and 343 specimens were extracted. The second-year surgeons had significantly higher accuracy rates than first-year surgeons (81.5 % vs. 69.0 %, p = 0.013), while PDD experience did not significantly affect accuracy rates (76.5, 75.5, and 69.0 %). In addition, the accuracy rate was also significantly lower in tangential effect areas (59.6 % vs. 80.8 %). Multivariate analysis identified urological experience as a significant factor improving accuracy rate (odds ratio [OR] 2.14) while tangential effects substantially reduced accuracy rate (OR 0.37). Notably, combining both PDD and WL resulted in a sensitivity exceeding 94 %, even in first-year urology residents and tangential effect areas. Conclusions: Urological experience had a greater impact on diagnostic performance of PDD compared to PDD experience. The combination of PDD and WL findings may improve sensitivity and reduce the possibility of missed diagnoses for less experienced urology residents. |
| format | Article |
| id | doaj-art-bd6b3b40c22d48b1a472986cb27ac903 |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-bd6b3b40c22d48b1a472986cb27ac9032025-02-01T04:11:40ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-02-0151104429Variations in the diagnostic performance of transurethral resection of bladder tumor with photodynamic diagnosis according to surgical experience: A retrospective, single-center studyShuhei Suzuki0Yoshiyuki Nagumo1Kosuke Kojo2Atsushi Ikeda3Bunpei Isoda4Akane Yamaguchi5Kozaburo Tanuma6Satoshi Nitta7Masanobu Shiga8Takashi Kawahara9Shuya Kandori10Akio Hoshi11Hiromitsu Negoro12Bryan J. Mathis13Hiroyuki Nishiyama14Department of Urology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanDepartment of Urology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanDepartment of Urology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanDepartment of Urology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; Corresponding author.Department of Urology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanDepartment of Urology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanDepartment of Urology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanDepartment of Urology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanDepartment of Urology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanDepartment of Urology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanDepartment of Urology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanDepartment of Urology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanDepartment of Urology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanDepartment of Cardiovascular Surgery, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanDepartment of Urology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanBackground: To investigate variations in diagnostic performance of photodynamic diagnosis (PDD) according to surgical experience. Methods: Data were extracted from patients having pT1 or lower primary tumors that underwent PDD-assisted transurethral resection of bladder tumors (TURBT) with orally 5-amibolevulinic acid at our institute. Surgical experience was categorized by urological experience (first-year and second-year) and PDD experience (<10, 10–19, and ≥20 cases). Sensitivity, specificity, and accuracy rates were calculated based on PDD or white light (WL) findings and pathologic diagnosis. The bladder neck, trigone, and prostatic urethra were defined as areas with a high probability of tangential effect. Results: A total of 108 patients and 343 specimens were extracted. The second-year surgeons had significantly higher accuracy rates than first-year surgeons (81.5 % vs. 69.0 %, p = 0.013), while PDD experience did not significantly affect accuracy rates (76.5, 75.5, and 69.0 %). In addition, the accuracy rate was also significantly lower in tangential effect areas (59.6 % vs. 80.8 %). Multivariate analysis identified urological experience as a significant factor improving accuracy rate (odds ratio [OR] 2.14) while tangential effects substantially reduced accuracy rate (OR 0.37). Notably, combining both PDD and WL resulted in a sensitivity exceeding 94 %, even in first-year urology residents and tangential effect areas. Conclusions: Urological experience had a greater impact on diagnostic performance of PDD compared to PDD experience. The combination of PDD and WL findings may improve sensitivity and reduce the possibility of missed diagnoses for less experienced urology residents.http://www.sciencedirect.com/science/article/pii/S1572100024004654Photodynamic diagnosisBladder cancerTransurethral resectionSurgical experience |
| spellingShingle | Shuhei Suzuki Yoshiyuki Nagumo Kosuke Kojo Atsushi Ikeda Bunpei Isoda Akane Yamaguchi Kozaburo Tanuma Satoshi Nitta Masanobu Shiga Takashi Kawahara Shuya Kandori Akio Hoshi Hiromitsu Negoro Bryan J. Mathis Hiroyuki Nishiyama Variations in the diagnostic performance of transurethral resection of bladder tumor with photodynamic diagnosis according to surgical experience: A retrospective, single-center study Photodiagnosis and Photodynamic Therapy Photodynamic diagnosis Bladder cancer Transurethral resection Surgical experience |
| title | Variations in the diagnostic performance of transurethral resection of bladder tumor with photodynamic diagnosis according to surgical experience: A retrospective, single-center study |
| title_full | Variations in the diagnostic performance of transurethral resection of bladder tumor with photodynamic diagnosis according to surgical experience: A retrospective, single-center study |
| title_fullStr | Variations in the diagnostic performance of transurethral resection of bladder tumor with photodynamic diagnosis according to surgical experience: A retrospective, single-center study |
| title_full_unstemmed | Variations in the diagnostic performance of transurethral resection of bladder tumor with photodynamic diagnosis according to surgical experience: A retrospective, single-center study |
| title_short | Variations in the diagnostic performance of transurethral resection of bladder tumor with photodynamic diagnosis according to surgical experience: A retrospective, single-center study |
| title_sort | variations in the diagnostic performance of transurethral resection of bladder tumor with photodynamic diagnosis according to surgical experience a retrospective single center study |
| topic | Photodynamic diagnosis Bladder cancer Transurethral resection Surgical experience |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024004654 |
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