Cereblon: A Protein Crucial to the Multiple Functions of Immunomodulatory Drugs as well as Cell Metabolism and Disease Generation
It is well known that cereblon is a key protein in autosomal recessive nonsyndromic mental retardation. Studies have reported that it has an intermediary role in helping immunomodulatory drugs perform their immunomodulatory and tumoricidal effects. In addition, cereblon also regulates the expression...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/9130608 |
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| _version_ | 1832545464312922112 |
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| author | Qinglin Shi Lijuan Chen |
| author_facet | Qinglin Shi Lijuan Chen |
| author_sort | Qinglin Shi |
| collection | DOAJ |
| description | It is well known that cereblon is a key protein in autosomal recessive nonsyndromic mental retardation. Studies have reported that it has an intermediary role in helping immunomodulatory drugs perform their immunomodulatory and tumoricidal effects. In addition, cereblon also regulates the expression, assembly, and activities of other special proteins related to cell proliferation and metabolism, resulting in the occurrence and development of metabolic diseases. This review details the multiple functions of cereblon and the underlying mechanisms. We also put forward some unsolved problems, including the intrinsic mechanism of cereblon function and the possible regulatory mechanisms of its expression. |
| format | Article |
| id | doaj-art-bd6067a5dac94c0a9daabd73349e33ab |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-bd6067a5dac94c0a9daabd73349e33ab2025-02-03T07:25:49ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/91306089130608Cereblon: A Protein Crucial to the Multiple Functions of Immunomodulatory Drugs as well as Cell Metabolism and Disease GenerationQinglin Shi0Lijuan Chen1Department of Hematology, The First Affiliated Hospital of Nanjing Medical University/Jiangsu Province Hospital, 300 Guangzhou Road, Nanjing 210029, ChinaDepartment of Hematology, The First Affiliated Hospital of Nanjing Medical University/Jiangsu Province Hospital, 300 Guangzhou Road, Nanjing 210029, ChinaIt is well known that cereblon is a key protein in autosomal recessive nonsyndromic mental retardation. Studies have reported that it has an intermediary role in helping immunomodulatory drugs perform their immunomodulatory and tumoricidal effects. In addition, cereblon also regulates the expression, assembly, and activities of other special proteins related to cell proliferation and metabolism, resulting in the occurrence and development of metabolic diseases. This review details the multiple functions of cereblon and the underlying mechanisms. We also put forward some unsolved problems, including the intrinsic mechanism of cereblon function and the possible regulatory mechanisms of its expression.http://dx.doi.org/10.1155/2017/9130608 |
| spellingShingle | Qinglin Shi Lijuan Chen Cereblon: A Protein Crucial to the Multiple Functions of Immunomodulatory Drugs as well as Cell Metabolism and Disease Generation Journal of Immunology Research |
| title | Cereblon: A Protein Crucial to the Multiple Functions of Immunomodulatory Drugs as well as Cell Metabolism and Disease Generation |
| title_full | Cereblon: A Protein Crucial to the Multiple Functions of Immunomodulatory Drugs as well as Cell Metabolism and Disease Generation |
| title_fullStr | Cereblon: A Protein Crucial to the Multiple Functions of Immunomodulatory Drugs as well as Cell Metabolism and Disease Generation |
| title_full_unstemmed | Cereblon: A Protein Crucial to the Multiple Functions of Immunomodulatory Drugs as well as Cell Metabolism and Disease Generation |
| title_short | Cereblon: A Protein Crucial to the Multiple Functions of Immunomodulatory Drugs as well as Cell Metabolism and Disease Generation |
| title_sort | cereblon a protein crucial to the multiple functions of immunomodulatory drugs as well as cell metabolism and disease generation |
| url | http://dx.doi.org/10.1155/2017/9130608 |
| work_keys_str_mv | AT qinglinshi cereblonaproteincrucialtothemultiplefunctionsofimmunomodulatorydrugsaswellascellmetabolismanddiseasegeneration AT lijuanchen cereblonaproteincrucialtothemultiplefunctionsofimmunomodulatorydrugsaswellascellmetabolismanddiseasegeneration |