Multicentric Castleman’s Disease, Associated with Idiopathic Thrombocytopenic Purpura
The most common cause of a neck mass in young adults is hyperplastic lymphadenopathy consequent to infection and inflammation. Castleman’s disease (CD), an unusual benign lymphoproliferative disorder, infrequently causes neck masses. It occurs in unicentric (UCD) and multicentric (MCD) forms and is...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/269268 |
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| _version_ | 1832561038352973824 |
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| author | Ruchi Sood Harris C. Taylor Hamed Daw |
| author_facet | Ruchi Sood Harris C. Taylor Hamed Daw |
| author_sort | Ruchi Sood |
| collection | DOAJ |
| description | The most common cause of a neck mass in young adults is hyperplastic lymphadenopathy consequent to infection and inflammation. Castleman’s disease (CD), an unusual benign lymphoproliferative disorder, infrequently causes neck masses. It occurs in unicentric (UCD) and multicentric (MCD) forms and is associated with human immunodeficiency virus (HIV), human herpes virus 8 (HHV-8), and Kaposi's sarcoma. We present the third known association between MCD and previous immune thrombocytopenia in the absence of HIV and HHV-8 infection and review its association with other autoimmune disorders and attendant implications for pathogenesis. Finally, we summarize the current approach to therapy. |
| format | Article |
| id | doaj-art-bd4a094cf55245b6b2dcfd2996baaf26 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-bd4a094cf55245b6b2dcfd2996baaf262025-02-03T01:26:08ZengWileyCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/269268269268Multicentric Castleman’s Disease, Associated with Idiopathic Thrombocytopenic PurpuraRuchi Sood0Harris C. Taylor1Hamed Daw2Fairview Hospital, Cleveland Clinic Health System, Cleveland, OH 44111, USAFairview Hospital, Cleveland Clinic Health System, Cleveland, OH 44111, USAHematology-Oncology, Fairview Hospital, Cleveland Clinic Health System, Cleveland, OH 44111, USAThe most common cause of a neck mass in young adults is hyperplastic lymphadenopathy consequent to infection and inflammation. Castleman’s disease (CD), an unusual benign lymphoproliferative disorder, infrequently causes neck masses. It occurs in unicentric (UCD) and multicentric (MCD) forms and is associated with human immunodeficiency virus (HIV), human herpes virus 8 (HHV-8), and Kaposi's sarcoma. We present the third known association between MCD and previous immune thrombocytopenia in the absence of HIV and HHV-8 infection and review its association with other autoimmune disorders and attendant implications for pathogenesis. Finally, we summarize the current approach to therapy.http://dx.doi.org/10.1155/2013/269268 |
| spellingShingle | Ruchi Sood Harris C. Taylor Hamed Daw Multicentric Castleman’s Disease, Associated with Idiopathic Thrombocytopenic Purpura Case Reports in Hematology |
| title | Multicentric Castleman’s Disease, Associated with Idiopathic Thrombocytopenic Purpura |
| title_full | Multicentric Castleman’s Disease, Associated with Idiopathic Thrombocytopenic Purpura |
| title_fullStr | Multicentric Castleman’s Disease, Associated with Idiopathic Thrombocytopenic Purpura |
| title_full_unstemmed | Multicentric Castleman’s Disease, Associated with Idiopathic Thrombocytopenic Purpura |
| title_short | Multicentric Castleman’s Disease, Associated with Idiopathic Thrombocytopenic Purpura |
| title_sort | multicentric castleman s disease associated with idiopathic thrombocytopenic purpura |
| url | http://dx.doi.org/10.1155/2013/269268 |
| work_keys_str_mv | AT ruchisood multicentriccastlemansdiseaseassociatedwithidiopathicthrombocytopenicpurpura AT harrisctaylor multicentriccastlemansdiseaseassociatedwithidiopathicthrombocytopenicpurpura AT hameddaw multicentriccastlemansdiseaseassociatedwithidiopathicthrombocytopenicpurpura |