Intestinal Type of Lung Adenocarcinoma in Younger Adults
Intestinal type of lung adenocarcinoma (ILADC) was initially described by Tsao and Fraser in 1991. Morphology and immunophenotype of ILADC are the same as in colorectal adenocarcinoma. Rectocolonoscopy must be performed to exclude colorectal origin of adenocarcinoma. Colorectal adenocarcinoma claime...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Pulmonology |
| Online Access: | http://dx.doi.org/10.1155/2014/282196 |
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| author | Jelena Stojsic Milica Kontic Dragan Subotic Marko Popovic Dragana Tomasevic Jelena Lukic |
| author_facet | Jelena Stojsic Milica Kontic Dragan Subotic Marko Popovic Dragana Tomasevic Jelena Lukic |
| author_sort | Jelena Stojsic |
| collection | DOAJ |
| description | Intestinal type of lung adenocarcinoma (ILADC) was initially described by Tsao and Fraser in 1991. Morphology and immunophenotype of ILADC are the same as in colorectal adenocarcinoma. Rectocolonoscopy must be performed to exclude colorectal origin of adenocarcinoma. Colorectal adenocarcinoma claimed to be genetically similar to an ILADC. Patients. We describe 24- and 26-year-old patients of both genders who went under surgery because of a lung tumor mass detected on CT scan. ILADC was diagnosed on resected lung specimens. According to positivity of Cytokeratin20, CDX-2, and Villin, respectively, and negativity of Cytokeratin7, TTF-1, Napsin-A, SurfactantB, MUC-1, and MUC-2, respectively, ILADC was diagnosed. KRAS mutation was detected in tumor tissue of the male patient. Conclusion. Rectocolonoscopy is the only relevant method for distinguishing the intestinal type of lung adenocarcinoma from metastatic colorectal carcinoma because immunohistochemistry and detection of mutation status are frequently the same in both types of adenocarcinoma. More investigations are needed for further understanding of ILADC in purpose of personalized lung carcinoma therapy particularly introducing detection of mutation status, especially in younger patients. |
| format | Article |
| id | doaj-art-bd3577c6224c443bb5af4358a338961f |
| institution | Kabale University |
| issn | 2090-6846 2090-6854 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pulmonology |
| spelling | doaj-art-bd3577c6224c443bb5af4358a338961f2025-02-03T01:00:58ZengWileyCase Reports in Pulmonology2090-68462090-68542014-01-01201410.1155/2014/282196282196Intestinal Type of Lung Adenocarcinoma in Younger AdultsJelena Stojsic0Milica Kontic1Dragan Subotic2Marko Popovic3Dragana Tomasevic4Jelena Lukic5Service of Histopathology, Clinical Centre of Serbia, Koste Todorovića, 26, 11000 Belgrade, SerbiaClinic of Pulmonology, Clinical Centre of Serbia, Koste Todorovića, 26, 11000 Belgrade, SerbiaClinic of Thoracic Surgery, Clinical Centre of Serbia, Koste Todorovića, 26, 11000 Belgrade, SerbiaClinic of Thoracic Surgery, Clinical Centre of Serbia, Koste Todorovića, 26, 11000 Belgrade, SerbiaLaboratory for Biochemistry and Molecular Diagnostics, “Konzilijum,” Višegradska, 25, 11000 Belgrade, SerbiaLaboratory for Biochemistry and Molecular Diagnostics, “Konzilijum,” Višegradska, 25, 11000 Belgrade, SerbiaIntestinal type of lung adenocarcinoma (ILADC) was initially described by Tsao and Fraser in 1991. Morphology and immunophenotype of ILADC are the same as in colorectal adenocarcinoma. Rectocolonoscopy must be performed to exclude colorectal origin of adenocarcinoma. Colorectal adenocarcinoma claimed to be genetically similar to an ILADC. Patients. We describe 24- and 26-year-old patients of both genders who went under surgery because of a lung tumor mass detected on CT scan. ILADC was diagnosed on resected lung specimens. According to positivity of Cytokeratin20, CDX-2, and Villin, respectively, and negativity of Cytokeratin7, TTF-1, Napsin-A, SurfactantB, MUC-1, and MUC-2, respectively, ILADC was diagnosed. KRAS mutation was detected in tumor tissue of the male patient. Conclusion. Rectocolonoscopy is the only relevant method for distinguishing the intestinal type of lung adenocarcinoma from metastatic colorectal carcinoma because immunohistochemistry and detection of mutation status are frequently the same in both types of adenocarcinoma. More investigations are needed for further understanding of ILADC in purpose of personalized lung carcinoma therapy particularly introducing detection of mutation status, especially in younger patients.http://dx.doi.org/10.1155/2014/282196 |
| spellingShingle | Jelena Stojsic Milica Kontic Dragan Subotic Marko Popovic Dragana Tomasevic Jelena Lukic Intestinal Type of Lung Adenocarcinoma in Younger Adults Case Reports in Pulmonology |
| title | Intestinal Type of Lung Adenocarcinoma in Younger Adults |
| title_full | Intestinal Type of Lung Adenocarcinoma in Younger Adults |
| title_fullStr | Intestinal Type of Lung Adenocarcinoma in Younger Adults |
| title_full_unstemmed | Intestinal Type of Lung Adenocarcinoma in Younger Adults |
| title_short | Intestinal Type of Lung Adenocarcinoma in Younger Adults |
| title_sort | intestinal type of lung adenocarcinoma in younger adults |
| url | http://dx.doi.org/10.1155/2014/282196 |
| work_keys_str_mv | AT jelenastojsic intestinaltypeoflungadenocarcinomainyoungeradults AT milicakontic intestinaltypeoflungadenocarcinomainyoungeradults AT dragansubotic intestinaltypeoflungadenocarcinomainyoungeradults AT markopopovic intestinaltypeoflungadenocarcinomainyoungeradults AT draganatomasevic intestinaltypeoflungadenocarcinomainyoungeradults AT jelenalukic intestinaltypeoflungadenocarcinomainyoungeradults |