Obstructive Sleep Apnea Endophenotypes
Obstructive sleep apnea (OSA) is a common disorder with major neurocognitive and cardiometabolic consequences. It is now recognized as a heterogeneous disease with multiple different underlying mechanisms (endotypes) as well as variable clinical expression of disease (phenotypes). The importance of...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Revinter Publicações Ltda.
2025-03-01
|
| Series: | Sleep Science |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1788287 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849738042348142592 |
|---|---|
| author | Janna Rae Raphelson Ana Lucia Fuentes Breanna Holloway Atul Malhotra |
| author_facet | Janna Rae Raphelson Ana Lucia Fuentes Breanna Holloway Atul Malhotra |
| author_sort | Janna Rae Raphelson |
| collection | DOAJ |
| description | Obstructive sleep apnea (OSA) is a common disorder with major neurocognitive and cardiometabolic consequences. It is now recognized as a heterogeneous disease with multiple different underlying mechanisms (endotypes) as well as variable clinical expression of disease (phenotypes). The importance of this variability is emphasized since one variable in isolation typically explains only a fraction of the variance in OSA occurrence. This review provides an update of what is known regarding OSA heterogeneity. The importance of OSA endotypes is discussed in the context of how mechanism might affect disease management and/or design of subsequent randomized trials. Further research is recommended to provide further validation of OSA endophenotypes and how this information may influence clinical management in the future. |
| format | Article |
| id | doaj-art-bd2e47ca82fc4a4c98a3b1eaef76cfc6 |
| institution | DOAJ |
| issn | 1984-0659 1984-0063 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Sleep Science |
| spelling | doaj-art-bd2e47ca82fc4a4c98a3b1eaef76cfc62025-08-20T03:06:43ZengThieme Revinter Publicações Ltda.Sleep Science1984-06591984-00632025-03-011801e109e11310.1055/s-0044-1788287Obstructive Sleep Apnea EndophenotypesJanna Rae Raphelson0Ana Lucia Fuentes1Breanna Holloway2Atul Malhotra3https://orcid.org/0000-0002-9509-1827School of Medicine, University of California San Diego, La Jolla, CA, United StatesSchool of Medicine, University of California San Diego, La Jolla, CA, United StatesSchool of Medicine, University of California San Diego, La Jolla, CA, United StatesSchool of Medicine, University of California San Diego, La Jolla, CA, United StatesObstructive sleep apnea (OSA) is a common disorder with major neurocognitive and cardiometabolic consequences. It is now recognized as a heterogeneous disease with multiple different underlying mechanisms (endotypes) as well as variable clinical expression of disease (phenotypes). The importance of this variability is emphasized since one variable in isolation typically explains only a fraction of the variance in OSA occurrence. This review provides an update of what is known regarding OSA heterogeneity. The importance of OSA endotypes is discussed in the context of how mechanism might affect disease management and/or design of subsequent randomized trials. Further research is recommended to provide further validation of OSA endophenotypes and how this information may influence clinical management in the future.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1788287sleeplunghypoxemiaarousal |
| spellingShingle | Janna Rae Raphelson Ana Lucia Fuentes Breanna Holloway Atul Malhotra Obstructive Sleep Apnea Endophenotypes Sleep Science sleep lung hypoxemia arousal |
| title | Obstructive Sleep Apnea Endophenotypes |
| title_full | Obstructive Sleep Apnea Endophenotypes |
| title_fullStr | Obstructive Sleep Apnea Endophenotypes |
| title_full_unstemmed | Obstructive Sleep Apnea Endophenotypes |
| title_short | Obstructive Sleep Apnea Endophenotypes |
| title_sort | obstructive sleep apnea endophenotypes |
| topic | sleep lung hypoxemia arousal |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1788287 |
| work_keys_str_mv | AT jannaraeraphelson obstructivesleepapneaendophenotypes AT analuciafuentes obstructivesleepapneaendophenotypes AT breannaholloway obstructivesleepapneaendophenotypes AT atulmalhotra obstructivesleepapneaendophenotypes |