Peri-Traumatic Near-Infrared Light Treatment Attenuates the Severity of Noise-Induced Hearing Loss by Rescuing (Type I) Spiral Ganglion Neurons in Mice
Background: Previous studies have shown that multiple post-traumatic irradiations of the cochlea with near-infrared light (NIR) can significantly reduce noise-induced hearing loss. However, a single NIR pre-treatment was shown to have the same effect. Extending the pre-treatment time did not result...
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2025-01-01
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| author | Max Meuser Susanne Schwitzer Parisa Faraji Arne Ernst Dietmar Basta |
| author_facet | Max Meuser Susanne Schwitzer Parisa Faraji Arne Ernst Dietmar Basta |
| author_sort | Max Meuser |
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| description | Background: Previous studies have shown that multiple post-traumatic irradiations of the cochlea with near-infrared light (NIR) can significantly reduce noise-induced hearing loss. However, a single NIR pre-treatment was shown to have the same effect. Extending the pre-treatment time did not result in any further reduction in hearing loss. The present study investigated whether a combined NIR pre- and post-treatment had an increased effect on hearing preservation. Methods: Frequency-specific auditory brainstem potential thresholds (ABR) were determined in young adult mice. One group (n = 8) underwent NIR irradiation (808 nm, 120 mW, 15 min) of the cochlea, followed by a 30 min noise exposure (5–20 kHz, 115 dB SPL). A post-NIR treatment was administered for 30 min immediately following the noise trauma. After 14 days, hearing loss was determined by ABR measurements. The results were compared with a trauma-only group (n = 8) and an untreated control group (n = 5). Subsequently, the spiral ganglion neuron density was investigated. Results: A peri-traumatic NIR treatment resulted in a significantly lower hearing loss compared to the trauma-only group. Hearing protection in these animals significantly exceeded the effect of an exclusive pre- or post-treatment across all frequencies. A loss of spiral ganglion neurons in the trauma-only group was observed, which was significantly rescued by the peri-traumatic NIR treatment. Conclusions: A single peri-traumatic NIR treatment seems to be the more effective approach for the preservation of hearing thresholds after noise trauma compared to an isolated pre- or post-treatment. One target of the protective effect seems to be the spiral ganglion. |
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| institution | Kabale University |
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| spelling | doaj-art-bd25aa892f484924bc6296b1622ed7e92025-01-24T13:25:51ZengMDPI AGBrain Sciences2076-34252025-01-011516210.3390/brainsci15010062Peri-Traumatic Near-Infrared Light Treatment Attenuates the Severity of Noise-Induced Hearing Loss by Rescuing (Type I) Spiral Ganglion Neurons in MiceMax Meuser0Susanne Schwitzer1Parisa Faraji2Arne Ernst3Dietmar Basta4Department of Otolaryngology at Unfallkrankenhaus Berlin, Charité Medical School, University of Berlin, 12683 Berlin, GermanyDepartment of Otolaryngology at Unfallkrankenhaus Berlin, Charité Medical School, University of Berlin, 12683 Berlin, GermanyDepartment of Otolaryngology at Unfallkrankenhaus Berlin, Charité Medical School, University of Berlin, 12683 Berlin, GermanyDepartment of Otolaryngology at Unfallkrankenhaus Berlin, Charité Medical School, University of Berlin, 12683 Berlin, GermanyDepartment of Otolaryngology at Unfallkrankenhaus Berlin, Charité Medical School, University of Berlin, 12683 Berlin, GermanyBackground: Previous studies have shown that multiple post-traumatic irradiations of the cochlea with near-infrared light (NIR) can significantly reduce noise-induced hearing loss. However, a single NIR pre-treatment was shown to have the same effect. Extending the pre-treatment time did not result in any further reduction in hearing loss. The present study investigated whether a combined NIR pre- and post-treatment had an increased effect on hearing preservation. Methods: Frequency-specific auditory brainstem potential thresholds (ABR) were determined in young adult mice. One group (n = 8) underwent NIR irradiation (808 nm, 120 mW, 15 min) of the cochlea, followed by a 30 min noise exposure (5–20 kHz, 115 dB SPL). A post-NIR treatment was administered for 30 min immediately following the noise trauma. After 14 days, hearing loss was determined by ABR measurements. The results were compared with a trauma-only group (n = 8) and an untreated control group (n = 5). Subsequently, the spiral ganglion neuron density was investigated. Results: A peri-traumatic NIR treatment resulted in a significantly lower hearing loss compared to the trauma-only group. Hearing protection in these animals significantly exceeded the effect of an exclusive pre- or post-treatment across all frequencies. A loss of spiral ganglion neurons in the trauma-only group was observed, which was significantly rescued by the peri-traumatic NIR treatment. Conclusions: A single peri-traumatic NIR treatment seems to be the more effective approach for the preservation of hearing thresholds after noise trauma compared to an isolated pre- or post-treatment. One target of the protective effect seems to be the spiral ganglion.https://www.mdpi.com/2076-3425/15/1/62noise-induced hearing lossnear-infrared lightspiral ganglion neurons |
| spellingShingle | Max Meuser Susanne Schwitzer Parisa Faraji Arne Ernst Dietmar Basta Peri-Traumatic Near-Infrared Light Treatment Attenuates the Severity of Noise-Induced Hearing Loss by Rescuing (Type I) Spiral Ganglion Neurons in Mice Brain Sciences noise-induced hearing loss near-infrared light spiral ganglion neurons |
| title | Peri-Traumatic Near-Infrared Light Treatment Attenuates the Severity of Noise-Induced Hearing Loss by Rescuing (Type I) Spiral Ganglion Neurons in Mice |
| title_full | Peri-Traumatic Near-Infrared Light Treatment Attenuates the Severity of Noise-Induced Hearing Loss by Rescuing (Type I) Spiral Ganglion Neurons in Mice |
| title_fullStr | Peri-Traumatic Near-Infrared Light Treatment Attenuates the Severity of Noise-Induced Hearing Loss by Rescuing (Type I) Spiral Ganglion Neurons in Mice |
| title_full_unstemmed | Peri-Traumatic Near-Infrared Light Treatment Attenuates the Severity of Noise-Induced Hearing Loss by Rescuing (Type I) Spiral Ganglion Neurons in Mice |
| title_short | Peri-Traumatic Near-Infrared Light Treatment Attenuates the Severity of Noise-Induced Hearing Loss by Rescuing (Type I) Spiral Ganglion Neurons in Mice |
| title_sort | peri traumatic near infrared light treatment attenuates the severity of noise induced hearing loss by rescuing type i spiral ganglion neurons in mice |
| topic | noise-induced hearing loss near-infrared light spiral ganglion neurons |
| url | https://www.mdpi.com/2076-3425/15/1/62 |
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