Identification of the pyroptosis, apoptosis, and necroptosis (PANoptosis) involved in osteogenic differentiation inhibition impaired by tumor necrosis factor-α

Identification of the pyroptosis, apoptosis, and necroptosis (PANoptosis) involved in osteogenic differentiation inhibition impaired by tumor necrosis factor-α

Abstract Background Inflammatory diseases of the bones often result in excessive release of inflammatory cytokines and impaired osteogenic differentiation. Tumor necrosis factor‐α (TNF-α) is an important inflammatory cytokine in disease, and implicated in developing PANoptosis. Although TNF-α has ca...

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Bibliographic Details
Main Authors: Chang-liang Xia, Fei Liang, Jia-xuan Li, Yudun Qu, Wei Zhang, Suanji Ou, Yang Yang, Yong Qi, Chang-peng Xu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:European Journal of Medical Research
Subjects:
TNF-α
PANoptosis
Inflammatory bone disease
NLRP3
Online Access:https://doi.org/10.1186/s40001-025-02702-4
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